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    Prss55 serine protease 55 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683415, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prss55provided by RGD
    Official Full Name
    serine protease 55provided by RGD
    Primary source
    RGD:1586875
    See related
    EnsemblRapid:ENSRNOG00000047258 AllianceGenome:RGD:1586875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in acrosomal vesicle; cytosol; and plasma membrane. Orthologous to human PRSS55 (serine protease 55). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 147.5) and Brain (RPKM 26.5) See more
    Orthologs
    NEW
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    Genomic context

    See Prss55 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (42489022..42507310, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (38297674..38345059, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (47433575..47470809, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 8 open reading frame 74 Neighboring gene uncharacterized LOC120097016 Neighboring gene RP1 like 1 Neighboring gene serine protease 51 Neighboring gene protease, serine 52 Neighboring gene methionine sulfoxide reductase A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine protease 55
    Names
    protease, serine, 55

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433060.1NP_001419989.1  serine protease 55 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6H1, M0RBY1
    2. NM_001433061.1NP_001419990.1  serine protease 55 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
    3. NM_001433062.1NP_001419991.1  serine protease 55 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
    4. NM_001433063.1NP_001419992.1  serine protease 55 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      42489022..42507310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274876.1XP_063130946.1  serine protease 55 isoform X2

    2. XM_039093920.2XP_038949848.1  serine protease 55 isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:1164
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_039093918.2XP_038949846.1  serine protease 55 isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:1164
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_008770800.4XP_008769022.1  serine protease 55 isoform X1

      Related
      ENSRNOP00000103614.1, ENSRNOT00000145614.1
      Conserved Domains (1) summary
      cd00190
      Location:35264
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    5. XM_063274877.1XP_063130947.1  serine protease 55 isoform X2

    6. XM_063274878.1XP_063130948.1  serine protease 55 isoform X3