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    Sra1 steroid receptor RNA activator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sra1provided by RGD
    Official Full Name
    steroid receptor RNA activator 1provided by RGD
    Primary source
    RGD:621148
    See related
    EnsemblRapid:ENSRNOG00000018089 AllianceGenome:RGD:621148
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables nuclear receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in negative regulation of myoblast differentiation. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cell leading edge; intercellular bridge; and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human SRA1 (steroid receptor RNA activator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 404.4), Liver (RPKM 343.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sra1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28543347..28547474, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28269192..28273023, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29494004..29497232, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene SLC35A4 upstream open reading frame protein-like Neighboring gene Riken cDNA E230025N22 gene like Neighboring gene amyloid beta precursor protein binding family B member 3 Neighboring gene solute carrier family 35, member A4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Idiopathic Hypogonadotropic Hypogonadism Caused by Inactivating Mutations in SRA1. Kotan LD, et al. J Clin Res Pediatr Endocrinol, 2016 Jun 5. PMID 27086651, Free PMC Article
    2. Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA. McKay DB, et al. J Mol Biol, 2014 Apr 17. PMID 24486609, Free PMC Article
    3. A novel steroid receptor co-activator protein (SRAP) as an alternative form of steroid receptor RNA-activator gene: expression in prostate cancer cells and enhancement of androgen receptor activity. Kawashima H, et al. Biochem J, 2003 Jan 1. PMID 12350225, Free PMC Article
    4. Identification of new human coding steroid receptor RNA activator isoforms. Emberley E, et al. Biochem Biophys Res Commun, 2003 Feb 7. PMID 12565891
    5. Steroid receptor RNA activator affects the development of poststroke depression by regulating the peroxisome proliferator-activated receptor γ signaling pathway. Jiang B, et al. Neuroreport, 2020 Jan 8. PMID 31714481, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Steroid receptor RNA activator affects the development of poststroke depression by regulating the peroxisome proliferator-activated receptor gamma signaling pathway.
      Title: Steroid receptor RNA activator affects the development of poststroke depression by regulating the peroxisome proliferator-activated receptor γ signaling pathway.
    2. CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation
      Title: CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables steroid receptor RNA activator RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables steroid receptor RNA activator RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid receptor RNA activator RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables steroid receptor RNA activator RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    steroid receptor RNA activator 1
    Names
    SRAP
    steroid receptor RNA activator protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183329.3 → NP_899158.3  steroid receptor RNA activator 1

      See identical proteins and their annotated locations for NP_899158.3

      Status: PROVISIONAL

      Source sequence(s)
      AY542868, CB322787
      UniProtKB/Swiss-Prot
      Q6QGW5, Q811X7
      UniProtKB/TrEMBL
      A6J320, G3V8C6
      Related
      ENSRNOP00000024671.3, ENSRNOT00000024671.7
      Conserved Domains (1) summary
      pfam07304
      Location:78 → 210
      SRA1; Steroid receptor RNA activator (SRA1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      28543347..28547474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096578.2 → XP_038952506.1  steroid receptor RNA activator 1 isoform X1

      UniProtKB/TrEMBL
      Q5BKE4
      Conserved Domains (1) summary
      pfam07304
      Location:78 → 166
      SRA1; Steroid receptor RNA activator (SRA1)

    RNA

    1. XR_010059546.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6QGW5.2 GenPept UniProtKB/Swiss-Prot:Q6QGW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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