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    Gstm4 glutathione S-transferase mu 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499689, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gstm4provided by RGD
    Official Full Name
    glutathione S-transferase mu 4provided by RGD
    Primary source
    RGD:1565825
    See related
    EnsemblRapid:ENSRNOG00000019221 AllianceGenome:RGD:1565825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GSTM4-4
    Summary
    Predicted to enable several functions, including glutathione binding activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to be involved in glutathione metabolic process and long-chain fatty acid biosynthetic process. Predicted to act upstream of or within nitrobenzene metabolic process and xenobiotic catabolic process. Predicted to be located in cytosol and intercellular bridge. Orthologous to human GSTM4 (glutathione S-transferase mu 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 256.8), Lung (RPKM 112.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gstm4 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198356114..198373487, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195667940..195685315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210834013..210839242, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 2 Neighboring gene glutathione S-transferase mu 1 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene small nucleolar RNA SNORD47 Neighboring gene adenosine monophosphate deaminase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes. Comstock KE, et al. Arch Biochem Biophys, 1994 Jun. PMID 8203914
    2. Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme. Guo J, et al. Biochem J, 2002 Sep 15. PMID 12069689, Free PMC Article
    3. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Dalli J, et al. Proc Natl Acad Sci U S A, 2016 Oct 25. PMID 27791009, Free PMC Article
    4. Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. Ross VL, et al. Biochem J, 1993 Sep 1. PMID 8373352, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108896

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-C4 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-C4 synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-C4 synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within nitrobenzene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase Mu 4
    Names
    GST class-mu 4
    glutathione S-transferase M4
    glutathione S-transferase mu 3
    leukotriene C4 synthase GSTM4
    NP_001019475.1
    XP_038958863.1
    XP_038958864.1
    XP_038958865.1
    XP_038958868.1
    XP_063138472.1
    XP_063138473.1
    XP_063138474.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024304.1 → NP_001019475.1  glutathione S-transferase Mu 4

      See identical proteins and their annotated locations for NP_001019475.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091199
      UniProtKB/Swiss-Prot
      Q5BK56
      UniProtKB/TrEMBL
      B6DYQ3
      Related
      ENSRNOP00000025939.4, ENSRNOT00000025939.7
      Conserved Domains (2) summary
      cd03209
      Location:92 → 211
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:3 → 84
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198356114..198373487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102937.2 → XP_038958865.1  glutathione S-transferase Mu 4 isoform X4

      Conserved Domains (2) summary
      cd03075
      Location:3 → 84
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:92 → 120
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. XM_039102935.2 → XP_038958863.1  glutathione S-transferase Mu 4 isoform X1

      Conserved Domains (2) summary
      cd03209
      Location:45 → 164
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cl00388
      Location:3 → 37
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. XM_039102936.2 → XP_038958864.1  glutathione S-transferase Mu 4 isoform X2

      Conserved Domains (2) summary
      cd03209
      Location:43 → 162
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cl00388
      Location:3 → 37
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    4. XM_039102940.2 → XP_038958868.1  glutathione S-transferase Mu 4 isoform X5

      UniProtKB/TrEMBL
      A6HUX5
      Conserved Domains (1) summary
      cl02776
      Location:1 → 107
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    5. XM_063282403.1 → XP_063138473.1  glutathione S-transferase Mu 4 isoform X5

      UniProtKB/TrEMBL
      A6HUX5

    6. XM_063282404.1 → XP_063138474.1  glutathione S-transferase Mu 4 isoform X6

    7. XM_063282402.1 → XP_063138472.1  glutathione S-transferase Mu 4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK56.1 GenPept UniProtKB/Swiss-Prot:Q5BK56

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