U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Notch4 notch receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 406162, updated on 9-Dec-2024

    Summary

    Official Symbol
    Notch4provided by RGD
    Official Full Name
    notch receptor 4provided by RGD
    Primary source
    RGD:1303282
    See related
    EnsemblRapid:ENSRNOG00000000442 AllianceGenome:RGD:1303282
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; Notch binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in endothelial cell morphogenesis and luteolysis. Predicted to be located in cell surface; cytoplasmic vesicle; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 59.6), Heart (RPKM 41.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Notch4 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4164969..4189072, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4160362..4184466, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4329794..4353868)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene PBX homeobox 2 Neighboring gene G-protein signaling modulator 3 Neighboring gene serine/threonine kinase 19 pseudogene Neighboring gene complement C4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in luteolysis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mammary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in morphogenesis of a branching structure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion molecule production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of aorta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within venous blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neurogenic locus notch homolog protein 4
    Names
    notch 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002827.1NP_001002827.1  neurogenic locus notch homolog protein 4 precursor

      See identical proteins and their annotated locations for NP_001002827.1

      Status: PROVISIONAL

      Source sequence(s)
      BX883044
      UniProtKB/TrEMBL
      A6KTE6, A6KTE7, F7EQS6, Q6MG89
      Related
      ENSRNOP00000000513.4, ENSRNOT00000000513.6
      Conserved Domains (8) summary
      cd00054
      Location:429470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00204
      Location:16251732
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00066
      Location:12451281
      Notch; LNR domain
      pfam06816
      Location:12911337
      NOD; NOTCH protein
      pfam07645
      Location:191224
      EGF_CA; Calcium-binding EGF domain
      pfam07684
      Location:13761415
      NODP; NOTCH protein
      pfam12796
      Location:16301723
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:16261656
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4164969..4189072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098929.1XP_038954857.1  neurogenic locus notch homolog protein 4 isoform X4

      Conserved Domains (9) summary
      smart00004
      Location:771809
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:12051387
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:116152
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:11941224
      ANK; ANK repeat [structural motif]
      pfam00008
      Location:298328
      EGF; EGF-like domain
      pfam00066
      Location:819848
      Notch; LNR domain
      pfam06816
      Location:859908
      NOD; NOTCH protein
      pfam12796
      Location:11981291
      Ank_2; Ankyrin repeats (3 copies)
      cd21705
      Location:10041079
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    2. XM_039098927.1XP_038954855.1  neurogenic locus notch homolog protein 4 isoform X2

      Conserved Domains (10) summary
      smart00004
      Location:779817
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:12131395
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK07003
      Location:10183
      PRK07003; DNA polymerase III subunit gamma/tau
      cd00054
      Location:542576
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:12021232
      ANK; ANK repeat [structural motif]
      pfam00008
      Location:306336
      EGF; EGF-like domain
      pfam00066
      Location:827856
      Notch; LNR domain
      pfam06816
      Location:867916
      NOD; NOTCH protein
      pfam12796
      Location:12061299
      Ank_2; Ankyrin repeats (3 copies)
      cd21705
      Location:10121087
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    3. XM_039098930.2XP_038954858.1  neurogenic locus notch homolog protein 4 isoform X5

      Conserved Domains (9) summary
      smart00004
      Location:736774
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:11701352
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:499533
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:11591189
      ANK; ANK repeat [structural motif]
      pfam00008
      Location:263293
      EGF; EGF-like domain
      pfam00066
      Location:784813
      Notch; LNR domain
      pfam06816
      Location:824873
      NOD; NOTCH protein
      pfam12796
      Location:11631256
      Ank_2; Ankyrin repeats (3 copies)
      cd21705
      Location:9691044
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    4. XM_039098926.2XP_038954854.1  neurogenic locus notch homolog protein 4 isoform X1

      UniProtKB/TrEMBL
      A6KTE7
      Conserved Domains (8) summary
      smart00004
      Location:12031241
      NL; Domain found in Notch and Lin-12
      cd00054
      Location:429470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:16261656
      ANK; ANK repeat [structural motif]
      pfam07645
      Location:191224
      EGF_CA; Calcium-binding EGF domain
      pfam00066
      Location:12511280
      Notch; LNR domain
      pfam06816
      Location:12911340
      NOD; NOTCH protein
      pfam12796
      Location:16301723
      Ank_2; Ankyrin repeats (3 copies)
      cd21705
      Location:14361511
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    5. XM_039098928.2XP_038954856.1  neurogenic locus notch homolog protein 4 isoform X3

      UniProtKB/TrEMBL
      A6KTE7
      Conserved Domains (6) summary
      smart00004
      Location:12031241
      NL; Domain found in Notch and Lin-12
      cd00054
      Location:429470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:191224
      EGF_CA; Calcium-binding EGF domain
      pfam00066
      Location:12511280
      Notch; LNR domain
      pfam06816
      Location:12911340
      NOD; NOTCH protein
      cd21705
      Location:14361511
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    6. XM_039098931.2XP_038954859.1  neurogenic locus notch homolog protein 4 isoform X6

      UniProtKB/TrEMBL
      A6KTE8
      Conserved Domains (5) summary
      smart00004
      Location:12031241
      NL; Domain found in Notch and Lin-12
      cd00054
      Location:429470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:191224
      EGF_CA; Calcium-binding EGF domain
      pfam00066
      Location:12511280
      Notch; LNR domain
      pfam06816
      Location:12911340
      NOD; NOTCH protein