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    Entr1 endosome associated trafficking regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306322, updated on 9-Dec-2024

    Summary

    Official Symbol
    Entr1provided by RGD
    Official Full Name
    endosome associated trafficking regulator 1provided by RGD
    Primary source
    RGD:1305930
    See related
    EnsemblRapid:ENSRNOG00000018876 AllianceGenome:RGD:1305930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sdccag3
    Summary
    Predicted to be involved in several processes, including endocytic recycling; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Predicted to be located in endosome. Predicted to be part of retromer complex. Predicted to be active in endosome; microtubule organizing center; and midbody. Orthologous to human ENTR1 (endosome associated trafficking regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 411.0), Kidney (RPKM 271.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Entr1 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29599059..29605780, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9200967..9207688, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3827498..3834219, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene DNL-type zinc finger Neighboring gene caspase recruitment domain family, member 9 Neighboring gene small nuclear RNA activating complex, polypeptide 4 Neighboring gene peptidase, mitochondrial processing subunit alpha Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endosome-associated-trafficking regulator 1
    Names
    serologically defined colon cancer antigen 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013135.2NP_001013153.2  endosome-associated-trafficking regulator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JTE3, F1LMK3
      Related
      ENSRNOP00000058381.3, ENSRNOT00000061669.6
      Conserved Domains (2) summary
      TIGR02168
      Location:251373
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      NF033928
      Location:335431
      alph_xenorhab_A; alpha-xenorhabdolysin family binary toxin subunit A

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      29599059..29605780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283534.1XP_063139604.1  endosome-associated-trafficking regulator 1 isoform X8

    2. XM_006233681.5XP_006233743.1  endosome-associated-trafficking regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2U5, A6JTE3
      Related
      ENSRNOP00000084886.1, ENSRNOT00000105263.2
      Conserved Domains (1) summary
      cl23720
      Location:228335
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. XM_039104801.2XP_038960729.1  endosome-associated-trafficking regulator 1 isoform X7

    4. XM_006233682.5XP_006233744.1  endosome-associated-trafficking regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AUN1
      Related
      ENSRNOP00000096122.1, ENSRNOT00000102669.2
      Conserved Domains (1) summary
      cl23720
      Location:201308
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. XM_039104800.2XP_038960728.1  endosome-associated-trafficking regulator 1 isoform X6

      Conserved Domains (2) summary
      TIGR02168
      Location:170292
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      NF033928
      Location:254350
      alph_xenorhab_A; alpha-xenorhabdolysin family binary toxin subunit A
    6. XM_039104798.2XP_038960726.1  endosome-associated-trafficking regulator 1 isoform X3

      Conserved Domains (2) summary
      TIGR02168
      Location:193315
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      NF033928
      Location:277373
      alph_xenorhab_A; alpha-xenorhabdolysin family binary toxin subunit A
    7. XM_039104802.2XP_038960730.1  endosome-associated-trafficking regulator 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6ARC0
    8. XM_006233685.5XP_006233747.1  endosome-associated-trafficking regulator 1 isoform X5

      See identical proteins and their annotated locations for XP_006233747.1

      UniProtKB/TrEMBL
      A0A0G2JTN0
      Related
      ENSRNOP00000068774.2, ENSRNOT00000089705.3
      Conserved Domains (1) summary
      cl23720
      Location:178285
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    9. XM_039104799.2XP_038960727.1  endosome-associated-trafficking regulator 1 isoform X4

      Conserved Domains (2) summary
      TIGR02168
      Location:180302
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      NF033928
      Location:264360
      alph_xenorhab_A; alpha-xenorhabdolysin family binary toxin subunit A
    10. XM_063283535.1XP_063139605.1  endosome-associated-trafficking regulator 1 isoform X9

    RNA

    1. XR_005501844.2 RNA Sequence

    2. XR_010064608.1 RNA Sequence

    3. XR_010064607.1 RNA Sequence