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    Serhl2 serine hydrolase-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500911, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serhl2provided by RGD
    Official Full Name
    serine hydrolase-like 2provided by RGD
    Primary source
    RGD:1563386
    See related
    EnsemblRapid:ENSRNOG00000022932 AllianceGenome:RGD:1563386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563386
    Summary
    Predicted to enable hydrolase activity. Predicted to be located in cytoplasmic vesicle. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 175.5), Heart (RPKM 175.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Serhl2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116126085..116146345)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114246035..114266298)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123963381..123990103)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NFAT activating protein with ITAM motif 1 Neighboring gene uncharacterized LOC103692952 Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene DNA polymerase delta interacting protein 3 Neighboring gene RNA, U12 small nuclear

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. Sadusky TJ, et al. Genomics, 2001 Apr 1. PMID 11352564
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine hydrolase-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130579.2 → NP_001124051.1  serine hydrolase-like protein 2

      See identical proteins and their annotated locations for NP_001124051.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HT81, D4A071
      Conserved Domains (2) summary
      COG0596
      Location:15 → 302
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:28 → 137
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      116126085..116146345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765775.4 → XP_008763997.1  serine hydrolase-like protein 2 isoform X1

      Related
      ENSRNOP00000028962.4, ENSRNOT00000036586.5
      Conserved Domains (2) summary
      COG0596
      Location:33 → 320
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:46 → 155
      Abhydrolase_5; Alpha/beta hydrolase family

    2. XM_039079766.2 → XP_038935694.1  serine hydrolase-like protein 2 isoform X2

      Conserved Domains (1) summary
      COG0596
      Location:33 → 163
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RNA

    1. XR_010053032.1 RNA Sequence

    2. XR_010053031.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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