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    Slc16a8 solute carrier family 16 member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65200, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc16a8provided by RGD
    Official Full Name
    solute carrier family 16 member 8provided by RGD
    Primary source
    RGD:69282
    See related
    EnsemblRapid:ENSRNOG00000012090 AllianceGenome:RGD:69282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mct3
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in lactate transmembrane transport. Located in basal plasma membrane. Orthologous to human SLC16A8 (solute carrier family 16 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 4.5), Brain (RPKM 3.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc16a8 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112698701..112702496, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110818274..110822069, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120486266..120490192, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093688 Neighboring gene uncharacterized LOC134479937 Neighboring gene protein interacting with PRKCA 1 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene phospholipase A2 group VI

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE. Philp NJ, et al. Am J Physiol, 1998 Jun. PMID 9841555
    2. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). Wilson MC, et al. J Biol Chem, 2005 Jul 22. PMID 15917240
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables secondary active monocarboxylate transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 3
    Names
    solute carrier family 16 (monocarboxylate transporter), member 8
    solute carrier family 16 (monocarboxylic acid transporters), member 8
    solute carrier family 16, member 8 (monocarboxylic acid transporter 3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031744.2 → NP_113932.2  monocarboxylate transporter 3

      See identical proteins and their annotated locations for NP_113932.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      G3V7K8, O70461
      Related
      ENSRNOP00000016248.1, ENSRNOT00000016247.5
      Conserved Domains (1) summary
      TIGR00892
      Location:14 → 440
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112698701..112702496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595102.2 → XP_017450591.2  monocarboxylate transporter 3 isoform X1

      UniProtKB/Swiss-Prot
      G3V7K8, O70461
      Conserved Domains (1) summary
      TIGR00892
      Location:14 → 440
      2A0113; monocarboxylate transporter 1

    2. XM_063264226.1 → XP_063120296.1  monocarboxylate transporter 3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70461.2 GenPept UniProtKB/Swiss-Prot:O70461

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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