Grip1 glutamate receptor interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grip1provided by RGD
Official Full Name: glutamate receptor interacting protein 1provided by RGD
Primary source: RGD:621667
See related: EnsemblRapid:ENSRNOG00000004013 AllianceGenome:RGD:621667
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTPase binding activity; PDZ domain binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including nervous system development; positive regulation of cell projection organization; and regulation of neurotransmitter receptor activity. Located in several cellular components, including dendrite; spine synapse; and synaptic membrane. Part of exocyst. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in Fraser syndrome 3. Orthologous to human GRIP1 (glutamate receptor interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 48.3), Testes (RPKM 36.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (56820501..57477877)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (54934856..55592274)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (64672723..64854939)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings indicate that calpain-GRIP signaling is essential for the restabilization process that is associated with drug cue memory and the inhibition of calpain activity may be a novel strategy for the prevention of drug relapse.
Title: Calpain-GRIP Signaling in Nucleus Accumbens Core Mediates the Reconsolidation of Drug Reward Memory.
subcellular redistribution of GRIP1 and a change in the binding of GRIP1 to GluA2 during synaptic scaling, was observed.
Title: GRIP1 is required for homeostatic regulation of AMPAR trafficking.
Data show that glutamate receptor-interacting protein-1 (GRIP1) is recruited to synapses under conditions of hypoactivity.
Title: Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade.
Acute BDNF treatment upregulates the interactions between AMPA receptor subunits (GluR1 and GluR2) with their scaffold proteins SAP97 and GRIP1, respectively.
Title: Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression.
Our results suggest that spinal SGK1 phosphorylation, which subsequently triggers the GRASP-1/Rab4 cascade, plays a pivotal role in CFA-induced inflammatory pain by regulating GluR1-containing AMPAR recycling in the dorsal horn.
Title: Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats.
GRIP1d is a 135 kDa, 7-PDZ-domain variant of GRIP1, containing the 12 amino acid C-terminus originally described for the 4-PDZ-domain GRIP1c 4-7.
Title: Identification and characterization of two novel splice forms of GRIP1 in the rat brain.
These data indicate a novel mechanism of synaptic plasticity in which activation of M1 receptors results in AMPA receptor endocytosis, via a mechanism involving interactions between GluA2, GRIP and liprin-alpha.
Title: A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha.
We propose that GRIP1 palmitoylation modulates NMDA-induced AMPAR internalisation by differential regulation of the early endosomal system
Title: Differential roles of GRIP1a and GRIP1b in AMPA receptor trafficking.
GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions.
Title: GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions.
description of the three-dimensional structure of GRIP1 PDZ7 determined by NMR spectroscopy
Title: PDZ7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface area.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049021 (e-PCR)
- UniSTS:145469

AW530851 (e-PCR)
- UniSTS:244568

AU028173 (e-PCR)
- UniSTS:112586

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to brain-derived neurotrophic factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to phorbol 13-acetate 12-myristate	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendrite arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of AMPA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection arborization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of kainate selective glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic scaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport in synapse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine head	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine neck	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
part_of exocyst	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in spine synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor-interacting protein 1

Names: AMPA receptor-interacting protein GRIP1; GRIP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032069.1 → NP_114458.1 glutamate receptor-interacting protein 1

See identical proteins and their annotated locations for NP_114458.1

Status: PROVISIONAL

Source sequence(s)

U88572

UniProtKB/Swiss-Prot

P97879

UniProtKB/TrEMBL

A6IGX1

Related

ENSRNOP00000109468.1, ENSRNOT00000163589.1

Conserved Domains (1) summary

cd00992
Location:152 → 235

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

56820501..57477877

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079960.2 → XP_038935888.1 glutamate receptor-interacting protein 1 isoform X4

UniProtKB/TrEMBL

F1LMX8

Related

ENSRNOP00000086684.2, ENSRNOT00000095939.2

Conserved Domains (1) summary

cd00992
Location:153 → 236

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039079965.2 → XP_038935893.1 glutamate receptor-interacting protein 1 isoform X10

UniProtKB/TrEMBL

F1LMX8

Related

ENSRNOP00000089072.2, ENSRNOT00000103170.2

Conserved Domains (1) summary

cd00992
Location:126 → 209

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_063264315.1 → XP_063120385.1 glutamate receptor-interacting protein 1 isoform X9

UniProtKB/TrEMBL

A0A8I5Y580

Related

ENSRNOP00000073984.3, ENSRNOT00000088861.3
XM_063264314.1 → XP_063120384.1 glutamate receptor-interacting protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6GEA5

Related

ENSRNOP00000005539.7, ENSRNOT00000005539.9
XM_039079962.2 → XP_038935890.1 glutamate receptor-interacting protein 1 isoform X6

UniProtKB/TrEMBL

A0A8I6GEA5

Related

ENSRNOP00000005545.4, ENSRNOT00000005545.7

Conserved Domains (1) summary

cd00992
Location:151 → 234

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_063264317.1 → XP_063120387.1 glutamate receptor-interacting protein 1 isoform X13

UniProtKB/TrEMBL

A0A8I5Y580
XM_063264316.1 → XP_063120386.1 glutamate receptor-interacting protein 1 isoform X12

UniProtKB/TrEMBL

A0A8I5Y580
XM_063264320.1 → XP_063120390.1 glutamate receptor-interacting protein 1 isoform X16

UniProtKB/TrEMBL

A0A8I6GGW0
XM_039079963.2 → XP_038935891.1 glutamate receptor-interacting protein 1 isoform X7

UniProtKB/TrEMBL

A6IGX1, Q30A71

Conserved Domains (1) summary

cd00992
Location:152 → 235

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_063264319.1 → XP_063120389.1 glutamate receptor-interacting protein 1 isoform X15

UniProtKB/TrEMBL

A0A0G2K6Y0
XM_063264321.1 → XP_063120391.1 glutamate receptor-interacting protein 1 isoform X17

UniProtKB/TrEMBL

A0A0G2K6Y0
XM_039079961.2 → XP_038935889.1 glutamate receptor-interacting protein 1 isoform X5

UniProtKB/TrEMBL

A0A8I6AEY6, A6IGX0, A6IGX1

Related

ENSRNOP00000091086.1, ENSRNOT00000107252.2

Conserved Domains (1) summary

cd00992
Location:152 → 235

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039079966.2 → XP_038935894.1 glutamate receptor-interacting protein 1 isoform X11

UniProtKB/TrEMBL

A6IGX1

Related

ENSRNOP00000059908.5, ENSRNOT00000064448.6

Conserved Domains (1) summary

cd00992
Location:125 → 208

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_063264318.1 → XP_063120388.1 glutamate receptor-interacting protein 1 isoform X14

UniProtKB/TrEMBL

A0A0G2K6Y0
XM_039079958.2 → XP_038935886.1 glutamate receptor-interacting protein 1 isoform X1

UniProtKB/TrEMBL

F1LMX8

Conserved Domains (1) summary

cd00992
Location:196 → 279

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_063264313.1 → XP_063120383.1 glutamate receptor-interacting protein 1 isoform X2

UniProtKB/TrEMBL

F1LMX8
XM_039079964.2 → XP_038935892.1 glutamate receptor-interacting protein 1 isoform X8

UniProtKB/TrEMBL

A0A8I5Y580

Conserved Domains (1) summary

cd00992
Location:196 → 279

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039079967.2 → XP_038935895.1 glutamate receptor-interacting protein 1 isoform X18

UniProtKB/TrEMBL

Q30A72

Conserved Domains (1) summary

cd00992
Location:254 → 335

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039079969.2 → XP_038935897.1 glutamate receptor-interacting protein 1 isoform X20

UniProtKB/TrEMBL

A0A140TA96

Conserved Domains (1) summary

cd00992
Location:254 → 335

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039079968.2 → XP_038935896.1 glutamate receptor-interacting protein 1 isoform X19

Conserved Domains (1) summary

cd00992
Location:254 → 335

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039079970.1 → XP_038935898.1 glutamate receptor-interacting protein 1 isoform X21

Conserved Domains (1) summary

cd00992
Location:147 → 228

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...