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    Slc22a14 solute carrier family 22, member 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316061, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Slc22a14provided by RGD
    Official Full Name
    solute carrier family 22, member 14provided by RGD
    Primary source
    RGD:1306470
    See related
    EnsemblRapid:ENSRNOG00000042259 AllianceGenome:RGD:1306470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable riboflavin transmembrane transporter activity. Predicted to be involved in riboflavin transport and transmembrane transport. Predicted to act upstream of or within flagellated sperm motility and sperm capacitation. Predicted to be located in sperm principal piece. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC22A14 (solute carrier family 22 member 14). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 206.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc22a14 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127772275..127794222, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118894537..118916416, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127858425..127871192, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene phospholipase C, delta 1 Neighboring gene uncharacterized LOC102548352 Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene acetyl-Coenzyme A acyltransferase 1B Neighboring gene solute carrier family 22 member 13 Neighboring gene solute carrier family 22 member 13-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables riboflavin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in riboflavin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 14
    Names
    solute carrier family 22 (organic cation transporter), member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108193.2 → NP_001101663.2  solute carrier family 22 member 14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      E9PU08
      Related
      ENSRNOP00000052779.5, ENSRNOT00000055928.6
      Conserved Domains (1) summary
      cl28910
      Location:147 → 527
      MFS; Major Facilitator Superfamily

    2. NM_001393686.1 → NP_001380615.1  solute carrier family 22 member 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      B4F7B0
      Conserved Domains (1) summary
      cl28910
      Location:147 → 504
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      127772275..127794222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265653.1 → XP_063121723.1  solute carrier family 22 member 14 isoform X3

    2. XM_039081633.2 → XP_038937561.1  solute carrier family 22 member 14 isoform X1

      UniProtKB/TrEMBL
      E9PU08
      Conserved Domains (1) summary
      cl28910
      Location:147 → 527
      MFS; Major Facilitator Superfamily

    3. XM_063265652.1 → XP_063121722.1  solute carrier family 22 member 14 isoform X2

      UniProtKB/TrEMBL
      B4F7B0

    4. XM_039081637.2 → XP_038937565.1  solute carrier family 22 member 14 isoform X2

      UniProtKB/TrEMBL
      B4F7B0
      Conserved Domains (1) summary
      cl28910
      Location:147 → 504
      MFS; Major Facilitator Superfamily

    5. XM_039081631.2 → XP_038937559.1  solute carrier family 22 member 14 isoform X1

      UniProtKB/TrEMBL
      E9PU08
      Conserved Domains (1) summary
      cl28910
      Location:147 → 527
      MFS; Major Facilitator Superfamily

    6. XM_039081639.2 → XP_038937567.1  solute carrier family 22 member 14 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:147 → 527
      MFS; Major Facilitator Superfamily

    7. XM_039081634.2 → XP_038937562.1  solute carrier family 22 member 14 isoform X1

      UniProtKB/TrEMBL
      E9PU08
      Conserved Domains (1) summary
      cl28910
      Location:147 → 527
      MFS; Major Facilitator Superfamily

    8. XM_039081635.2 → XP_038937563.1  solute carrier family 22 member 14 isoform X1

      UniProtKB/TrEMBL
      E9PU08
      Conserved Domains (1) summary
      cl28910
      Location:147 → 527
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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