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    Slc19a3 solute carrier family 19 member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316559, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc19a3provided by RGD
    Official Full Name
    solute carrier family 19 member 3provided by RGD
    Primary source
    RGD:1311413
    See related
    EnsemblRapid:ENSRNOG00000057256 AllianceGenome:RGD:1311413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable thiamine transmembrane transporter activity. Predicted to be involved in pyridoxine transport; thiamine diphosphate biosynthetic process; and thiamine transmembrane transport. Predicted to be active in plasma membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in biotin-responsive basal ganglia disease. Orthologous to human SLC19A3 (solute carrier family 19 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 91.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc19a3 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (91723799..91747499, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (84275722..84299368, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (88762775..88828553, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L30-like Neighboring gene keratin-associated protein 5-2-like Neighboring gene small cysteine and glycine repeat-containing protein 6-like Neighboring gene C-C motif chemokine ligand 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. Bukhari FJ, et al. Nephrol Dial Transplant, 2011 Jul. PMID 21149507, Free PMC Article
    2. Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice. Reidling JC, et al. Gastroenterology, 2010 May. PMID 19879271, Free PMC Article
    3. Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine. Yamashiro T, et al. Drug Metab Pharmacokinet, 2022 Jun. PMID 35512554
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine.
      Title: Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables thiamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in pyridoxine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thiamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thiamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thiamine transporter 2
    Names
    solute carrier family 19 (sodium/hydrogen exchanger), member 3
    solute carrier family 19 (thiamine transporter), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432577.1 → NP_001419506.1  thiamine transporter 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JWB5

    2. NM_001432578.1 → NP_001419507.1  thiamine transporter 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JWB5

    3. NM_001432579.1 → NP_001419508.1  thiamine transporter 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JWB5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      91723799..91747499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083688.2 → XP_038939616.1  thiamine transporter 2 isoform X2

      UniProtKB/TrEMBL
      A6JWB5
      Conserved Domains (1) summary
      pfam01770
      Location:11 → 429
      Folate_carrier; Reduced folate carrier

    2. XM_039083686.2 → XP_038939614.1  thiamine transporter 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K171, A6JWB5
      Related
      ENSRNOP00000071722.2, ENSRNOT00000083667.3
      Conserved Domains (1) summary
      pfam01770
      Location:14 → 432
      Folate_carrier; Reduced folate carrier

    3. XM_039083687.2 → XP_038939615.1  thiamine transporter 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K171, A6JWB5
      Conserved Domains (1) summary
      pfam01770
      Location:14 → 432
      Folate_carrier; Reduced folate carrier

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108228.1: Suppressed sequence

      Description
      NM_001108228.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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