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    Sp100 SP100 nuclear antigen [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363269, updated on 9-Dec-2024

    Summary

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    Symbol
    Sp100provided by RGD
    Full Name
    SP100 nuclear antigenprovided by RGD
    Primary source
    RGD:1359550
    See related
    EnsemblRapid:ENSRNOG00000022769 AllianceGenome:RGD:1359550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; chromo shadow domain binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including innate immune response; regulation of DNA-templated transcription; and regulation of signal transduction. Predicted to be located in cytoplasm and nuclear lumen. Predicted to be part of Mre11 complex. Orthologous to human SP100 (SP100 nuclear antigen). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 236.2), Thymus (RPKM 138.4) and 8 other tissues See more
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    Genomic context

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    See Sp100 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (93758975..93825068)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (86310990..86377036)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (92675103..92718489)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480599 Neighboring gene component of Sp100-rs Neighboring gene SP110 nuclear body protein Neighboring gene SP140 nuclear body protein Neighboring gene RIKEN cDNA A630001G21 gene like Neighboring gene uncharacterized LOC103690562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. Szostecki C, et al. J Immunol, 1990 Dec 15. PMID 2258622
    2. The interferon (IFN)-stimulated gene Sp100 promoter contains an IFN-gamma activation site and an imperfect IFN-stimulated response element which mediate type I IFN inducibility. Grötzinger T, et al. J Biol Chem, 1996 Oct 11. PMID 8810287
    3. Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif. Guldner HH, et al. J Cell Sci, 1999 Mar. PMID 9973607
    4. Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex. Jiang WQ, et al. Mol Cell Biol, 2005 Apr. PMID 15767676, Free PMC Article
    5. Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expression. Negorev DG, et al. J Virol, 2006 Aug. PMID 16873258, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromo shadow domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of protein location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Fas signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to type I interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Mre11 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear autoantigen Sp-100
    Names
    nuclear antigen Sp100
    nuclear autoantigen Sp-100-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014220.1 → NP_001014242.1  nuclear autoantigen Sp-100 isoform 2

      See identical proteins and their annotated locations for NP_001014242.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083808
      UniProtKB/TrEMBL
      Q5XI80
      Conserved Domains (1) summary
      pfam03172
      Location:25 → 117
      Sp100; Sp100 domain

    2. NM_001401802.2 → NP_001388731.1  nuclear autoantigen Sp-100 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Related
      ENSRNOP00000084228.1, ENSRNOT00000111514.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      93758975..93825068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083898.2 → XP_038939826.1  nuclear autoantigen Sp-100 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Conserved Domains (4) summary
      cd15626
      Location:588 → 629
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:483 → 558
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:656 → 756
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    2. XM_039083903.2 → XP_038939831.1  nuclear autoantigen Sp-100 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Conserved Domains (4) summary
      cd15626
      Location:588 → 629
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:483 → 558
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:656 → 732
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    3. XM_039083907.2 → XP_038939835.1  nuclear autoantigen Sp-100 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Conserved Domains (4) summary
      cd15626
      Location:588 → 629
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:483 → 558
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:656 → 708
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    4. XM_039083911.2 → XP_038939839.1  nuclear autoantigen Sp-100 isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZMP9
      Conserved Domains (3) summary
      cd15626
      Location:588 → 629
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:483 → 558
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain

    5. XM_039083913.2 → XP_038939841.1  nuclear autoantigen Sp-100 isoform X22

      UniProtKB/TrEMBL
      A0A8I5ZMP9
      Conserved Domains (3) summary
      cd15626
      Location:588 → 629
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:483 → 558
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain

    6. XM_039083914.2 → XP_038939842.1  nuclear autoantigen Sp-100 isoform X28

      UniProtKB/TrEMBL
      A0A8I5ZMP9
      Conserved Domains (2) summary
      pfam01342
      Location:483 → 558
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain

    7. XM_063267437.1 → XP_063123507.1  nuclear autoantigen Sp-100 isoform X29

      UniProtKB/TrEMBL
      A0A8I5ZMP9

    8. XM_039083900.2 → XP_038939828.1  nuclear autoantigen Sp-100 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Related
      ENSRNOP00000079517.2, ENSRNOT00000112510.2
      Conserved Domains (4) summary
      cd15626
      Location:565 → 606
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:460 → 535
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:633 → 733
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    9. XM_063267424.1 → XP_063123494.1  nuclear autoantigen Sp-100 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZXL2

    10. XM_039083905.2 → XP_038939833.1  nuclear autoantigen Sp-100 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Related
      ENSRNOP00000081917.2, ENSRNOT00000111279.2
      Conserved Domains (4) summary
      cd15626
      Location:548 → 589
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:443 → 518
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:616 → 716
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    11. XM_039083902.2 → XP_038939830.1  nuclear autoantigen Sp-100 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Conserved Domains (4) summary
      cd15626
      Location:563 → 604
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:458 → 533
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:631 → 731
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    12. XM_039083908.2 → XP_038939836.1  nuclear autoantigen Sp-100 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Conserved Domains (4) summary
      cd15626
      Location:540 → 581
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:435 → 510
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:608 → 708
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    13. XM_039083910.2 → XP_038939838.1  nuclear autoantigen Sp-100 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Conserved Domains (4) summary
      cd15626
      Location:523 → 564
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:418 → 493
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:591 → 691
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    14. XM_063267435.1 → XP_063123505.1  nuclear autoantigen Sp-100 isoform X26

      UniProtKB/TrEMBL
      A0A8I5ZMP9

    15. XM_063267423.1 → XP_063123493.1  nuclear autoantigen Sp-100 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZXL2

    16. XM_063267427.1 → XP_063123497.1  nuclear autoantigen Sp-100 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZXL2

    17. XM_039083899.2 → XP_038939827.1  nuclear autoantigen Sp-100 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXL2, A0A8I6GKN6
      Related
      ENSRNOP00000093445.1, ENSRNOT00000110612.2
      Conserved Domains (4) summary
      cd15626
      Location:578 → 619
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:473 → 548
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:646 → 746
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    18. XM_063267432.1 → XP_063123502.1  nuclear autoantigen Sp-100 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZPT8, A0A8I5ZXL2
      Related
      ENSRNOP00000080041.1, ENSRNOT00000095650.2

    19. XM_063267439.1 → XP_063123509.1  nuclear autoantigen Sp-100 isoform X31

      UniProtKB/TrEMBL
      A0A8I6G6P9

    20. XM_039083909.2 → XP_038939837.1  nuclear autoantigen Sp-100 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Conserved Domains (4) summary
      cd15626
      Location:538 → 579
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:433 → 508
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:606 → 706
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    21. XM_063267440.1 → XP_063123510.1  nuclear autoantigen Sp-100 isoform X32

      UniProtKB/TrEMBL
      A0A0G2K6R2

    22. XM_063267426.1 → XP_063123496.1  nuclear autoantigen Sp-100 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Related
      ENSRNOP00000082712.2, ENSRNOT00000116342.2

    23. XM_063267428.1 → XP_063123498.1  nuclear autoantigen Sp-100 isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Related
      ENSRNOP00000033655.8, ENSRNOT00000034152.8

    24. XM_063267425.1 → XP_063123495.1  nuclear autoantigen Sp-100 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZXL2

    25. XM_063267429.1 → XP_063123499.1  nuclear autoantigen Sp-100 isoform X19

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Related
      ENSRNOP00000073910.3, ENSRNOT00000080956.3

    26. XM_039083912.2 → XP_038939840.1  nuclear autoantigen Sp-100 isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Conserved Domains (4) summary
      cd15626
      Location:513 → 554
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:408 → 483
      SAND; SAND domain
      pfam03172
      Location:23 → 119
      HSR; HSR domain
      cl02556
      Location:581 → 681
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    27. XM_063267431.1 → XP_063123501.1  nuclear autoantigen Sp-100 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZXL2

    28. XM_063267430.1 → XP_063123500.1  nuclear autoantigen Sp-100 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZXL2
      Related
      ENSRNOP00000097798.2, ENSRNOT00000102336.2

    29. XM_063267433.1 → XP_063123503.1  nuclear autoantigen Sp-100 isoform X24

      UniProtKB/TrEMBL
      A0A8I5ZXL2, A0A8I6ATB4

    30. XM_063267438.1 → XP_063123508.1  nuclear autoantigen Sp-100 isoform X30

      UniProtKB/TrEMBL
      A0A8I6G6P9

    31. XM_063267441.1 → XP_063123511.1  nuclear autoantigen Sp-100 isoform X33

      UniProtKB/TrEMBL
      A0A0G2K6R2

    32. XM_063267434.1 → XP_063123504.1  nuclear autoantigen Sp-100 isoform X25

      UniProtKB/TrEMBL
      A0A8I5ZXL2

    33. XM_063267436.1 → XP_063123506.1  nuclear autoantigen Sp-100 isoform X27

      UniProtKB/TrEMBL
      A0A8I5ZXL2

    34. XM_063267442.1 → XP_063123512.1  nuclear autoantigen Sp-100 isoform X34

    35. XM_039083915.2 → XP_038939843.1  nuclear autoantigen Sp-100 isoform X35

      Conserved Domains (1) summary
      pfam03172
      Location:23 → 119
      HSR; HSR domain

    36. XM_006245338.5 → XP_006245400.2  nuclear autoantigen Sp-100 isoform X36

      UniProtKB/TrEMBL
      F7FPF5
      Conserved Domains (1) summary
      pfam03172
      Location:23 → 119
      HSR; HSR domain

    RNA

    1. XR_005488939.2 RNA Sequence

    2. XR_010054616.1 RNA Sequence

    3. XR_010054615.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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