Trappc14 trafficking protein particle complex subunit 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trappc14provided by RGD
Official Full Name: trafficking protein particle complex subunit 14provided by RGD
Primary source: RGD:1305455
See related: EnsemblRapid:ENSRNOG00000039214 AllianceGenome:RGD:1305455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Map11; RGD1305455
Summary: Predicted to enable alpha-tubulin binding activity. Predicted to be involved in cilium assembly and regulation of cell population proliferation. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and plasma membrane. Predicted to be part of TRAPPII protein complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human TRAPPC14 (trafficking protein particle complex subunit 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 55.5), Spleen (RPKM 55.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (22376361..22380706, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (17262748..17267093, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (19577895..19582185, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TRAPPII protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRAPPII protein complex	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trafficking protein particle complex subunit 14

Names: microtubule associated protein 11; trafficking protein particle complex 14; uncharacterized protein C7orf43 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024969.2 → NP_001020140.2 trafficking protein particle complex subunit 14

Status: VALIDATED

Source sequence(s)

BC091263, CO394313, DY317491

UniProtKB/TrEMBL

A0A0G2KAX2

Related

ENSRNOP00000075560.1, ENSRNOT00000085853.3

Conserved Domains (1) summary

pfam15806
Location:139 → 579

DUF4707; Domain of unknown function (DUF4707)