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    Vwa5a von Willebrand factor A domain containing 5A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301097, updated on 9-Dec-2024

    Summary

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    Symbol
    Vwa5aprovided by RGD
    Full Name
    von Willebrand factor A domain containing 5Aprovided by RGD
    Primary source
    RGD:735145
    See related
    EnsemblRapid:ENSRNOG00000000195 AllianceGenome:RGD:735145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    masa-1; Loh11cr2a
    Summary
    Predicted to be located in nucleoplasm. Orthologous to human VWA5A (von Willebrand factor A domain containing 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 343.3), Lung (RPKM 181.5) and 9 other tissues See more
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    Genomic context

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    See Vwa5a in Genome Data Viewer
    Location:
    8q22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (47712352..47745847)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (38815176..38848674)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (42442932..42476417)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 8 subfamily B member 59 Neighboring gene olfactory receptor family 8 subfamily G member 51 Neighboring gene olfactory receptor family 8 subfamily B member 53C, pseudogene 1 Neighboring gene olfactory receptor family 8 subfamily B member 53

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23. Monaco C, et al. Genomics, 1997 Dec 1. PMID 9417908

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor A domain-containing protein 5A
    Names
    loss of heterozygosity 11 chromosomal region 2 gene A protein homolog
    loss of heterozygosity, 11, chromosomal region 2, gene A homolog
    mast cell surface antigen 1
    von Willebrand factor A domain-containing protein 5A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393948.1 → NP_001380877.1  von Willebrand factor A domain-containing protein 5A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A140TAB5
      Related
      ENSRNOP00000015986.9, ENSRNOT00000015986.9
      Conserved Domains (2) summary
      cd01461
      Location:278 → 456
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      cl02699
      Location:1 → 131
      VIT; Vault protein inter-alpha-trypsin domain

    RNA

    1. NR_172059.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      47712352..47745847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265315.1 → XP_063121385.1  von Willebrand factor A domain-containing protein 5A isoform X1

      UniProtKB/TrEMBL
      A0A140TAB5

    2. XM_039081323.2 → XP_038937251.1  von Willebrand factor A domain-containing protein 5A isoform X3

      UniProtKB/TrEMBL
      A0A0H2UH90, A0A140TAB5
      Conserved Domains (2) summary
      cd01461
      Location:278 → 456
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      cl02699
      Location:1 → 131
      VIT; Vault protein inter-alpha-trypsin domain

    3. XM_063265317.1 → XP_063121387.1  von Willebrand factor A domain-containing protein 5A isoform X2

      UniProtKB/Swiss-Prot
      Q75WE7
      UniProtKB/TrEMBL
      A0A140TAB5

    4. XM_063265319.1 → XP_063121389.1  von Willebrand factor A domain-containing protein 5A isoform X4

      UniProtKB/TrEMBL
      A0A140TAB5
      Related
      ENSRNOP00000000211.7, ENSRNOT00000000211.7

    5. XM_063265316.1 → XP_063121386.1  von Willebrand factor A domain-containing protein 5A isoform X1

      UniProtKB/TrEMBL
      A0A140TAB5

    6. XM_063265318.1 → XP_063121388.1  von Willebrand factor A domain-containing protein 5A isoform X3

      UniProtKB/TrEMBL
      A0A0H2UH90, A0A140TAB5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q75WE7.1 GenPept UniProtKB/Swiss-Prot:Q75WE7

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