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    Adam6 ADAM metallopeptidase domain 6A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192271, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam6provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 6Aprovided by RGD
    Primary source
    RGD:621472
    See related
    EnsemblRapid:ENSRNOG00000090919 AllianceGenome:RGD:621472
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adam6a; TMDCIV
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in male gonad development. Predicted to be located in cell surface. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Orthologous to human ADAM6 (ADAM metallopeptidase domain 6 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Adam6 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (138488008..138490496)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (132666974..132669462)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (138432550..138435038)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene prohibitin 1-like Neighboring gene DiGeorge syndrome critical region gene 2, pseudogene 1 Neighboring gene Ig heavy chain V region PJ14-like Neighboring gene Ig heavy chain V region PJ14-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. Marcello MR, et al. J Biol Chem, 2011 Apr 15. PMID 21339297, Free PMC Article
    2. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Rosselot C, et al. Dev Dyn, 2003 Jul. PMID 12815633
    3. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, et al. Mol Reprod Dev, 1997 Oct. PMID 9291465
    4. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Han C, et al. Biol Reprod, 2009 May. PMID 19129510
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADAM metallopeptidase domain 6A
    Names
    a disintegrin and metallopeptidase domain 6
    a disintegrin and metallopeptidase domain 6A
    a disintegrin and metalloproteinase domain 6
    tMDC IV

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138906.1 → NP_620261.1  ADAM metallopeptidase domain 6A precursor

      See identical proteins and their annotated locations for NP_620261.1

      Status: PROVISIONAL

      Source sequence(s)
      Y09111
      UniProtKB/TrEMBL
      A6KC05, P70535
      Related
      ENSRNOP00000107788.1, ENSRNOT00000149852.1
      Conserved Domains (4) summary
      smart00608
      Location:502 → 637
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:217 → 405
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:428 → 499
      Disintegrin; Disintegrin
      pfam01562
      Location:64 → 166
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      138488008..138490496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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