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    Zfp263 zinc finger protein 263 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp263provided by RGD
    Official Full Name
    zinc finger protein 263provided by RGD
    Primary source
    RGD:1307301
    See related
    EnsemblRapid:ENSRNOG00000007678 AllianceGenome:RGD:1307301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ZNF263 (zinc finger protein 263). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 52.6), Thymus (RPKM 45.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp263 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (12270785..12280982, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11764424..11774324, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (12023677..12035189, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480755 Neighboring gene uncharacterized LOC134480757 Neighboring gene uncharacterized LOC102551940 Neighboring gene uncharacterized LOC134480756 Neighboring gene MEFV innate immunity regulator, pyrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263. Frietze S, et al. J Biol Chem, 2010 Jan 8. PMID 19887448, Free PMC Article
    2. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 263

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399418.1 → NP_001386347.1  zinc finger protein 263

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZQ68
      Related
      ENSRNOP00000010442.6, ENSRNOT00000010442.8
      Conserved Domains (5) summary
      smart00431
      Location:41 → 151
      SCAN; leucine rich region
      COG5048
      Location:460 → 646
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436 → 456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:645 → 667
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:219 → 257
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      12270785..12280982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245831.5 → XP_006245893.1  zinc finger protein 263 isoform X1

      UniProtKB/TrEMBL
      A6K4V1
      Conserved Domains (7) summary
      cd07765
      Location:134 → 172
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:135 → 193
      KRAB; krueppel associated box
      COG5048
      Location:375 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:349 → 371
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:41 → 127
      SCAN; SCAN domain
      pfam13465
      Location:391 → 416
      zf-H2C2_2; Zinc-finger double domain

    2. XM_063268528.1 → XP_063124598.1  zinc finger protein 263 isoform X2

      UniProtKB/TrEMBL
      A6K4V2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105763.1: Suppressed sequence

      Description
      NM_001105763.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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