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    Trnau1ap tRNA selenocysteine 1 associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trnau1approvided by RGD
    Official Full Name
    tRNA selenocysteine 1 associated protein 1provided by RGD
    Primary source
    RGD:619995
    See related
    EnsemblRapid:ENSRNOG00000055344 AllianceGenome:RGD:619995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Secp43; Trspap1
    Summary
    Enables tRNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TRNAU1AP (tRNA selenocysteine 1 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 246.5), Muscle (RPKM 191.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trnau1ap in Genome Data Viewer
    Location:
    5q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149791631..149808149, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144507044..144524142, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150463797..150506803, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102992 Neighboring gene small nucleolar RNA, H/ACA box 61 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene regulator of chromosome condensation 1 Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene phosphatase and actin regulator 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte‑like H9c2 cells. Li MD, et al. Mol Med Rep, 2017 Feb. PMID 28101579
    2. Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine. Ding F, et al. RNA, 1999 Dec. PMID 10606267, Free PMC Article
    3. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. Xu XM, et al. J Biol Chem, 2005 Dec 16. PMID 16230358
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of Trnau1ap inhibits the proliferation of cardiomyocytelike H9c2 cells. Downregulation of Trnau1ap induces apoptosis.
      Title: Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte‑like H9c2 cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in selenocysteine incorporation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in selenocysteine incorporation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA selenocysteine 1-associated protein 1
    Names
    tRNA selenocysteine 1-associated protein 1-like
    tRNA selenocysteine associated protein
    tRNA selenocysteine-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411667.1 → NP_001398596.1  tRNA selenocysteine 1-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JZ46, A0A8I6A7J2
      Related
      ENSRNOP00000088939.1, ENSRNOT00000102379.2

    2. NM_001411668.1 → NP_001398597.1  tRNA selenocysteine 1-associated protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JZ46

    3. NM_001411669.1 → NP_001398598.1  tRNA selenocysteine 1-associated protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    4. NM_001411670.1 → NP_001398599.1  tRNA selenocysteine 1-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOP00000085714.2, ENSRNOT00000098219.2

    5. NM_001411671.1 → NP_001398600.1  tRNA selenocysteine 1-associated protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    6. NM_001411672.1 → NP_001398601.1  tRNA selenocysteine 1-associated protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    7. NM_001411673.1 → NP_001398602.1  tRNA selenocysteine 1-associated protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOP00000084120.2, ENSRNOT00000113510.2

    8. NM_001411674.1 → NP_001398603.1  tRNA selenocysteine 1-associated protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    9. NM_023027.2 → NP_075416.1  tRNA selenocysteine 1-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_075416.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9QZI7
      UniProtKB/TrEMBL
      A0A0G2JZ46
      Related
      ENSRNOP00000070906.2, ENSRNOT00000086131.3
      Conserved Domains (3) summary
      pfam17654
      Location:205 → 284
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cd12610
      Location:4 → 87
      RRM1_SECp43; RNA recognition motif 1 (RRM1) found in tRNA selenocysteine-associated protein 1 (SECp43)
      cd12612
      Location:95 → 176
      RRM2_SECp43; RNA recognition motif 2 (RRM2) found in tRNA selenocysteine-associated protein 1 (SECp43)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      149791631..149808149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110739.2 → XP_038966667.1  tRNA selenocysteine 1-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      A6ISS5
      Conserved Domains (2) summary
      pfam17654
      Location:70 → 149
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cl17169
      Location:4 → 42
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_039110734.2 → XP_038966662.1  tRNA selenocysteine 1-associated protein 1 isoform X1

      Conserved Domains (3) summary
      pfam17654
      Location:205 → 242
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cd12610
      Location:4 → 87
      RRM1_SECp43; RNA recognition motif 1 (RRM1) found in tRNA selenocysteine-associated protein 1 (SECp43)
      cd12612
      Location:95 → 176
      RRM2_SECp43; RNA recognition motif 2 (RRM2) found in tRNA selenocysteine-associated protein 1 (SECp43)

    3. XM_039110736.2 → XP_038966664.1  tRNA selenocysteine 1-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZ46
      Conserved Domains (3) summary
      pfam17654
      Location:161 → 240
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cd12610
      Location:4 → 87
      RRM1_SECp43; RNA recognition motif 1 (RRM1) found in tRNA selenocysteine-associated protein 1 (SECp43)
      cl17169
      Location:93 → 132
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_063288370.1 → XP_063144440.1  tRNA selenocysteine 1-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZ46

    RNA

    1. XR_005504536.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZI7.1 GenPept UniProtKB/Swiss-Prot:Q9QZI7

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