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    Vwa3b von Willebrand factor A domain containing 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501126, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vwa3bprovided by RGD
    Official Full Name
    von Willebrand factor A domain containing 3Bprovided by RGD
    Primary source
    RGD:1562560
    See related
    EnsemblRapid:ENSRNOG00000023566 AllianceGenome:RGD:1562560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 22. Orthologous to human VWA3B (von Willebrand factor A domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 174.8), Lung (RPKM 13.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vwa3b in Genome Data Viewer
    Location:
    9q21
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46746307..46915436)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (39249523..39419614)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43607066..43779466)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene zeta chain of T cell receptor associated protein kinase 70 Neighboring gene transmembrane protein 131 Neighboring gene uncharacterized LOC134480356 Neighboring gene transfer RNA alanine (anticodon AGC) 41 Neighboring gene uncharacterized LOC102554996 Neighboring gene uncharacterized LOC134480357 Neighboring gene cyclic nucleotide gated channel subunit alpha 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156769

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor A domain-containing protein 3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419961.1 → NP_001406890.1  von Willebrand factor A domain-containing protein 3B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZMT1
      Related
      ENSRNOP00000079290.2, ENSRNOT00000101179.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      46746307..46915436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084535.2 → XP_038940463.1  von Willebrand factor A domain-containing protein 3B isoform X4

      Conserved Domains (1) summary
      cd00198
      Location:511 → 656
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_063267598.1 → XP_063123668.1  von Willebrand factor A domain-containing protein 3B isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMT1
      Related
      ENSRNOP00000088328.2, ENSRNOT00000023617.7

    3. XM_063267599.1 → XP_063123669.1  von Willebrand factor A domain-containing protein 3B isoform X3

    4. XM_063267597.1 → XP_063123667.1  von Willebrand factor A domain-containing protein 3B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKI0, A0A8I6A6E4
      Related
      ENSRNOP00000078235.1, ENSRNOT00000088239.3

    RNA

    1. XR_010054626.1 RNA Sequence

    2. XR_010054627.1 RNA Sequence

    3. XR_594349.4 RNA Sequence

    4. XR_001839791.3 RNA Sequence

    5. XR_005489105.2 RNA Sequence

    6. XR_001839789.3 RNA Sequence

    7. XR_010054625.1 RNA Sequence

    8. XR_005489106.2 RNA Sequence

    9. XR_005489107.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024362.1: Suppressed sequence

      Description
      NM_001024362.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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