Phf10 PHD finger protein 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Phf10provided by RGD
Official Full Name: PHD finger protein 10provided by RGD
Primary source: RGD:1305266
See related: EnsemblRapid:ENSRNOG00000061312 AllianceGenome:RGD:1305266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BAF45a
Summary: Predicted to enable chromatin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Involved in embryonic brain development. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of npBAF complex. Predicted to be active in nucleus. Orthologous to human PHF10 (PHD finger protein 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 175.9), Testes (RPKM 161.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (64625373..64642110, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (55952249..55968994, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (56951516..56967893, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH142080 (e-PCR)
- UniSTS:224070

BF396946 (e-PCR)
- UniSTS:245887

RH132671 (e-PCR)
- UniSTS:215954

RH140578 (e-PCR)
- UniSTS:222647

RH130186 (e-PCR)
- UniSTS:213473

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in embryonic brain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of npBAF complex	IEA Inferred from Electronic Annotation more info
part_of npBAF complex	ISO Inferred from Sequence Orthology more info
part_of npBAF complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PHD finger protein 10

Names: BRG1-associated factor 45a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024747.3 → NP_001019918.3 PHD finger protein 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q4V7A6

UniProtKB/TrEMBL

A0A0G2K3M7

Related

ENSRNOP00000072702.3, ENSRNOT00000085273.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

64625373..64642110 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017588876.3 → XP_017444365.2 PHD finger protein 10 isoform X1

UniProtKB/TrEMBL

A0A0G2K3M7

Related

ENSRNOP00000020889.6, ENSRNOT00000020889.7

Conserved Domains (3) summary

cd15528
Location:438 → 491

PHD1_PHF10; PHD finger 1 found in PHD finger protein 10 (PHF10) and similar proteins

cd15529
Location:493 → 536

PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins

cd21085
Location:133 → 219

WH_NTD_PHF10; N-terminal winged helix DNA-binding domain found in PHD finger protein 10 (PHF10) and similar proteins