Cd244 CD244 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd244provided by RGD
Official Full Name: CD244 moleculeprovided by RGD
Primary source: RGD:9330179
See related: EnsemblRapid:ENSRNOG00000064255 AllianceGenome:RGD:9330179
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable MHC class I protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including natural killer cell activation involved in immune response; positive regulation of biosynthetic process; and positive regulation of lymphocyte proliferation. Predicted to be located in external side of plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 25.5), Lung (RPKM 4.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86583727..86606902)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (84051339..84082864)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89997710..90004364)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in myeloid dendritic cell activation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD8-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granzyme B production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: uncharacterized LOC103692282

Names: NK cell receptor 2B4; natural killer cell receptor 2B4; natural killer cell receptor 2B4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419604.1 → NP_001406533.1 uncharacterized LOC103692282 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

E9PT21, Q9EQK9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

86583727..86606902

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091419.2 → XP_038947347.1 uncharacterized LOC103692282 isoform X3

Conserved Domains (2) summary

cd00096
Location:25 → 27

Ig; Ig strand A [structural motif]

cl11960
Location:22 → 128

Ig; Immunoglobulin domain
XM_039091420.2 → XP_038947348.1 uncharacterized LOC103692282 isoform X4

Conserved Domains (2) summary

cd00096
Location:25 → 27

Ig; Ig strand A [structural motif]

cl11960
Location:22 → 128

Ig; Immunoglobulin domain
XM_039091416.2 → XP_038947344.1 uncharacterized LOC103692282 isoform X1

UniProtKB/TrEMBL

Q9EQK9

Conserved Domains (2) summary

cd00096
Location:25 → 27

Ig; Ig strand A [structural motif]

cl11960
Location:22 → 128

Ig; Immunoglobulin domain
XM_039091417.2 → XP_038947345.1 uncharacterized LOC103692282 isoform X2

UniProtKB/TrEMBL

Q9EQK9

Related

ENSRNOP00000006266.7, ENSRNOT00000006266.9

Conserved Domains (2) summary

cd00096
Location:25 → 27

Ig; Ig strand A [structural motif]

cl11960
Location:22 → 128

Ig; Immunoglobulin domain
XM_039091423.2 → XP_038947351.1 uncharacterized LOC103692282 isoform X5

UniProtKB/TrEMBL

A6JG03