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    ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Erinaceus europaeus (western European hedgehog) ]

    Gene ID: 103126780, updated on 3-Dec-2024

    Summary

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    Gene symbol
    ARHGEF6
    Gene description
    Rac/Cdc42 guanine nucleotide exchange factor 6
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Erinaceus europaeus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae; Erinaceus
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current mEriEur2.1 (GCF_950295315.1) X NC_080185.1 (21154341..21323229)
    101 previous assembly EriEur2.0 (GCF_000296755.1) Unplaced Scaffold NW_006805045.1 (74199..255359)

    Chromosome X - NC_080185.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD61 Neighboring gene RNA binding motif protein X-linked Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene CD40 ligand Neighboring gene vestigial like family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 6
    Names
    Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_950295315.1-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mEriEur2.1

    Genomic

    1. NC_080185.1 Reference mEriEur2.1

      Range
      21154341..21323229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007537689.3 → XP_007537751.1  rho guanine nucleotide exchange factor 6 isoform X1

      UniProtKB/TrEMBL
      A0A1S3ANB4, A0A1S3WV78
      Conserved Domains (8) summary
      cd12060
      Location:162 → 219
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:5 → 105
      CH; Calponin homology domain
      cd00160
      Location:242 → 419
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:450 → 547
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:467 → 548
      PH; PH domain
      pfam16523
      Location:681 → 767
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:574 → 678
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:115 → 160
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    2. XM_060183685.1 → XP_060039668.1  rho guanine nucleotide exchange factor 6 isoform X2

      UniProtKB/TrEMBL
      A0A1S3WV78

    3. XM_060183686.1 → XP_060039669.1  rho guanine nucleotide exchange factor 6 isoform X3

      UniProtKB/TrEMBL
      A0A1S3WV78
    Nucleotide Protein
    Heading Accession and Version

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