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    Tmem11 transmembrane protein 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem11provided by RGD
    Official Full Name
    transmembrane protein 11provided by RGD
    Primary source
    RGD:1309817
    See related
    EnsemblRapid:ENSRNOG00000005377 AllianceGenome:RGD:1309817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309817
    Summary
    Predicted to be involved in inner mitochondrial membrane organization. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human TMEM11 (transmembrane protein 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 206.3), Heart (RPKM 152.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem11 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46042251..46057065, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45542753..45557570, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47117133..47131842, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3, pseudogene 15 Neighboring gene dehydrogenase/reductase 7B Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC102546946 Neighboring gene N-acetyltransferase domain containing 1 Neighboring gene mitogen-activated protein kinase kinase 3, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. Rival T, et al. EMBO Rep, 2011 Mar. PMID 21274005, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in inner mitochondrial membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 11, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164543.1 → NP_001158015.1  transmembrane protein 11, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001158015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC158725
      UniProtKB/Swiss-Prot
      B0BN86
      UniProtKB/TrEMBL
      A0A8I6AHI0
      Conserved Domains (1) summary
      pfam14972
      Location:26 → 188
      Mito_morph_reg; Mitochondrial morphogenesis regulator

    2. NM_001166165.1 → NP_001159637.1  transmembrane protein 11, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001159637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC158725, DY316208
      UniProtKB/TrEMBL
      A0A0G2JUS7, A0A8I6AHI0
      Related
      ENSRNOP00000069213.1, ENSRNOT00000086206.3
      Conserved Domains (1) summary
      pfam14972
      Location:12 → 174
      Mito_morph_reg; Mitochondrial morphogenesis regulator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46042251..46057065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001113778.1: Suppressed sequence

      Description
      NM_001113778.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BN86.1 GenPept UniProtKB/Swiss-Prot:B0BN86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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