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    Skic3 SKI3 subunit of superkiller complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Skic3provided by RGD
    Official Full Name
    SKI3 subunit of superkiller complexprovided by RGD
    Primary source
    RGD:1306062
    See related
    EnsemblRapid:ENSRNOG00000040297 AllianceGenome:RGD:1306062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ttc37; RGD1306062
    Summary
    Predicted to be involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay and rescue of stalled ribosome. Predicted to be located in cytosol; euchromatin; and nucleoplasm. Predicted to be part of Ski complex. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 1. Orthologous to human SKIC3 (SKI3 subunit of superkiller complex). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 200.9), Spleen (RPKM 180.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Skic3 in Genome Data Viewer
    Location:
    2q11
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (7363417..7526351)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (5631544..5783643)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (2891265..3037602)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 150 Neighboring gene arylsulfatase family, member K Neighboring gene small nucleolar RNA SNORA17 Neighboring gene family with sequence similarity 81, member B Neighboring gene EWS RNA-binding protein 2 Neighboring gene multiple C2 and transmembrane domain containing 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human PAF complex coordinates transcription with events downstream of RNA synthesis. Zhu B, et al. Genes Dev, 2005 Jul 15. PMID 16024656, Free PMC Article
    2. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    3. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ski complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ski complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    superkiller complex protein 3
    Names
    tetratricopeptide repeat domain 37
    tetratricopeptide repeat protein 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427072.1 → NP_001414001.1  superkiller complex protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZL50

    2. NM_001427073.1 → NP_001414002.1  superkiller complex protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZL50
      Related
      ENSRNOP00000110267.1, ENSRNOT00000129988.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      7363417..7526351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281455.1 → XP_063137525.1  superkiller complex protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZL50

    2. XM_063281449.1 → XP_063137519.1  superkiller complex protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZL50

    3. XM_063281457.1 → XP_063137527.1  superkiller complex protein 3 isoform X3

      UniProtKB/TrEMBL
      D3ZL50

    4. XM_063281450.1 → XP_063137520.1  superkiller complex protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZL50

    5. XM_063281447.1 → XP_063137517.1  superkiller complex protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZL50

    6. XM_063281448.1 → XP_063137518.1  superkiller complex protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZL50
      Related
      ENSRNOP00000058722.6, ENSRNOT00000062017.7

    7. XM_063281456.1 → XP_063137526.1  superkiller complex protein 3 isoform X2

      UniProtKB/TrEMBL
      D3ZL50
      Related
      ENSRNOP00000101343.1, ENSRNOT00000142593.1

    8. XM_063281451.1 → XP_063137521.1  superkiller complex protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZL50

    9. XM_063281452.1 → XP_063137522.1  superkiller complex protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZL50

    10. XM_063281454.1 → XP_063137524.1  superkiller complex protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZL50

    11. XM_063281453.1 → XP_063137523.1  superkiller complex protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZL50
    Nucleotide Protein Strain
    Heading Accession and Version

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