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    Ric1 RIC1 homolog, RAB6A GEF complex partner 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309306, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ric1provided by RGD
    Official Full Name
    RIC1 homolog, RAB6A GEF complex partner 1provided by RGD
    Primary source
    RGD:1310016
    See related
    EnsemblRapid:ENSRNOG00000016172 AllianceGenome:RGD:1310016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310016
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Predicted to be located in membrane. Predicted to be part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. Predicted to be active in Golgi membrane and cytosol. Orthologous to human RIC1 (RIC1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 191.2), Thymus (RPKM 175.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ric1 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (236698901..236798099)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (227285510..227384553)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (247688778..247784219)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene programmed cell death 1 ligand 2 Neighboring gene uncharacterized LOC134485218 Neighboring gene uncharacterized LOC134485217 Neighboring gene endoplasmic reticulum metallopeptidase 1 Neighboring gene uncharacterized LOC120100017

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies. Unlu G, et al. Nat Med, 2020 Jan. PMID 31932796, Free PMC Article
    2. Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. Pusapati GV, et al. J Biol Chem, 2012 Dec 7. PMID 23091056, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cranial skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extracellular matrix constituent secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor subunit RIC1
    Names
    RAB6A GEF complex partner 1
    RAB6A-GEF complex partner protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427735.2 → NP_001414664.1  guanine nucleotide exchange factor subunit RIC1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I0W8, D4A224
      Related
      ENSRNOP00000098850.1, ENSRNOT00000141897.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      236698901..236798099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231255.5 → XP_006231317.1  guanine nucleotide exchange factor subunit RIC1 isoform X1

      See identical proteins and their annotated locations for XP_006231317.1

      UniProtKB/TrEMBL
      A6I0W8
      Conserved Domains (2) summary
      pfam07064
      Location:736 → 993
      RIC1; RIC1
      sd00039
      Location:254 → 304
      7WD40; WD40 repeat [structural motif]

    2. XM_006231256.5 → XP_006231318.1  guanine nucleotide exchange factor subunit RIC1 isoform X2

      See identical proteins and their annotated locations for XP_006231318.1

      UniProtKB/TrEMBL
      A6I0W8
      Conserved Domains (2) summary
      pfam07064
      Location:735 → 992
      RIC1; RIC1
      sd00039
      Location:253 → 303
      7WD40; WD40 repeat [structural motif]

    3. XM_039101403.2 → XP_038957331.1  guanine nucleotide exchange factor subunit RIC1 isoform X3

      UniProtKB/TrEMBL
      A6I0W8
      Conserved Domains (2) summary
      sd00039
      Location:139 → 189
      7WD40; WD40 repeat [structural motif]
      pfam07064
      Location:621 → 878
      RIC1
    Nucleotide Protein Strain
    Heading Accession and Version

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