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    Hikeshi heat shock protein nuclear import factor hikeshi [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hikeshiprovided by RGD
    Official Full Name
    heat shock protein nuclear import factor hikeshiprovided by RGD
    Primary source
    RGD:1359455
    See related
    EnsemblRapid:ENSRNOG00000017383 AllianceGenome:RGD:1359455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    l7Rn6
    Summary
    Predicted to enable Hsp70 protein binding activity and nuclear import signal receptor activity. Predicted to be involved in cellular response to heat and protein import into nucleus. Predicted to act upstream of or within Golgi organization and lung development. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 13. Orthologous to human HIKESHI (heat shock protein nuclear import factor hikeshi). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 154.9), Heart (RPKM 128.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hikeshi in Genome Data Viewer
    Location:
    1q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (153237948..153261856, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (143825399..143849361, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (154147098..154170429, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 17 Neighboring gene ferritin light chain 1-like Neighboring gene embryonic ectoderm development Neighboring gene large ribosomal subunit protein uL22-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage. Kose S, et al. Cell, 2012 Apr 27. PMID 22541429
    2. Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s. Song J, et al. Acta Crystallogr D Biol Crystallogr, 2015 Mar. PMID 25760597
    3. l7Rn6 encodes a novel protein required for clara cell function in mouse lung development. Fernández-Valdivia R, et al. Genetics, 2006 Jan. PMID 16157679, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp70 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein Hikeshi
    Names
    Hikeshi, heat shock protein nuclear import factor
    lethal, Chr 7, Rinchik 6
    uncharacterized protein C11orf73 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013897.2 → NP_001013919.1  protein Hikeshi isoform 2

      See identical proteins and their annotated locations for NP_001013919.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5M808
      Conserved Domains (1) summary
      pfam05603
      Location:1 → 156
      DUF775; Protein of unknown function (DUF775)

    2. NM_001398731.1 → NP_001385660.1  protein Hikeshi isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      G3V889, Q5M808
      Related
      ENSRNOP00000099709.1, ENSRNOT00000173309.1
      Conserved Domains (1) summary
      pfam05603
      Location:1 → 195
      DUF775; Protein of unknown function (DUF775)

    3. NM_001398732.1 → NP_001385661.1  protein Hikeshi isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I613
      Conserved Domains (1) summary
      pfam05603
      Location:7 → 96
      DUF775; Protein of unknown function (DUF775)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      153237948..153261856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759638.2 → XP_008757860.1  protein Hikeshi isoform X1

      See identical proteins and their annotated locations for XP_008757860.1

      UniProtKB/TrEMBL
      A6I613
      Conserved Domains (1) summary
      pfam05603
      Location:7 → 96
      DUF775; Protein of unknown function (DUF775)

    2. XM_063284886.1 → XP_063140956.1  protein Hikeshi isoform X1

      UniProtKB/TrEMBL
      A6I613
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M808.2 GenPept UniProtKB/Swiss-Prot:Q5M808

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