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    Ccdc186 coiled-coil domain containing 186 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361773, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc186provided by RGD
    Official Full Name
    coiled-coil domain containing 186provided by RGD
    Primary source
    RGD:1307158
    See related
    EnsemblRapid:ENSRNOG00000051680 AllianceGenome:RGD:1307158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307158
    Summary
    Predicted to act upstream of or within insulin secretion involved in cellular response to glucose stimulus; response to bacterium; and vesicle cytoskeletal trafficking. Predicted to be located in Golgi apparatus. Orthologous to human CCDC186 (coiled-coil domain containing 186). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 77.6), Brain (RPKM 73.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc186 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (265840429..265878082, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (255831663..255871954, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (277603601..277635379, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene adrenoceptor beta 1 Neighboring gene uncharacterized LOC102547814 Neighboring gene tudor domain containing 1 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene actin filament associated protein 1-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The dense-core vesicle maturation protein CCCP-1 binds RAB-2 and membranes through its C-terminal domain. Cattin-Ortolá J, et al. Traffic, 2017 Nov. PMID 28755404, Free PMC Article
    2. Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice. Wang G, et al. Cell Biosci, 2016. PMID 27293546, Free PMC Article
    3. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle cytoskeletal trafficking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle cytoskeletal trafficking ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 186

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427749.1 → NP_001414678.1  coiled-coil domain-containing protein 186

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7
      Related
      ENSRNOP00000095837.2, ENSRNOT00000114119.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      265840429..265878082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101450.2 → XP_038957378.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7
      Conserved Domains (1) summary
      COG1196
      Location:251 → 618
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_063268801.1 → XP_063124871.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7

    3. XM_063268797.1 → XP_063124867.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7

    4. XM_063268806.1 → XP_063124876.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7

    5. XM_063268788.1 → XP_063124858.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7

    6. XM_039101451.2 → XP_038957379.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7
      Conserved Domains (1) summary
      COG1196
      Location:251 → 618
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_039101454.2 → XP_038957382.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7
      Conserved Domains (1) summary
      COG1196
      Location:251 → 618
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_039101455.2 → XP_038957383.1  coiled-coil domain-containing protein 186 isoform X2

      UniProtKB/TrEMBL
      A0A8I6APJ7
      Related
      ENSRNOP00000074637.3, ENSRNOT00000080039.3
      Conserved Domains (1) summary
      COG1196
      Location:251 → 618
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    9. XM_039101453.2 → XP_038957381.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7
      Conserved Domains (1) summary
      COG1196
      Location:251 → 618
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    10. XM_063268792.1 → XP_063124862.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7

    11. XM_063268781.1 → XP_063124851.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7

    12. XM_063268789.1 → XP_063124859.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7

    13. XM_017590399.3 → XP_017445888.2  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7
      Conserved Domains (1) summary
      COG1196
      Location:251 → 618
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    14. XM_039101452.2 → XP_038957380.1  coiled-coil domain-containing protein 186 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8K1, A0A222NUN6, A0A8I6APJ7
      Conserved Domains (1) summary
      COG1196
      Location:251 → 618
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    15. XM_039101456.2 → XP_038957384.1  coiled-coil domain-containing protein 186 isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:176 → 533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:11 → 345
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    16. XM_063268813.1 → XP_063124883.1  coiled-coil domain-containing protein 186 isoform X4

    RNA

    1. XR_005499768.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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