Dlg2 discs large MAGUK scaffold protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dlg2provided by RGD
Full Name: discs large MAGUK scaffold protein 2provided by RGD
Primary source: RGD:619895
See related: EnsemblRapid:ENSRNOG00000022635 AllianceGenome:RGD:619895
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dlgh2
Summary: Enables PDZ domain binding activity and protein phosphatase binding activity. Involved in neuronal ion channel clustering and receptor clustering. Located in several cellular components, including dendrite; juxtaparanode region of axon; and neuronal cell body. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 332.3), Brain (RPKM 297.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (153864545..155916238)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (144451653..146503949)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (154916274..157274077)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A mild impairment in reversal learning in a bowl-digging substrate deterministic task but not other cognitive tests in the Dlg2+/- rat model of genetic risk for psychiatric disorder.
Title: A mild impairment in reversal learning in a bowl-digging substrate deterministic task but not other cognitive tests in the Dlg2+/- rat model of genetic risk for psychiatric disorder.
Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity.
Title: Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity.
Evidence supports PSD-93 as a new substrate of the synaptic species of ERK; ERK2 possesses the ability to interact with PSD-93 and phosphorylate PSD-93 at a specific site.
Title: Interactions and phosphorylation of postsynaptic density 93 (PSD-93) by extracellular signal-regulated kinase (ERK).
The homogenous distribution of PSD-95 and PSD-93 throughout the PSD is consistent with their being part of a backbone that stabilizes their various binding partners within the PSD.
Title: Distribution of the scaffolding proteins PSD-95, PSD-93, and SAP97 in isolated PSDs.
spinal cord PSD-93/chapsin-110 might be involved in the central mechanism of chronic pain.
Title: Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH144233 (e-PCR)
- UniSTS:233478

BE121387 (e-PCR)
- UniSTS:248077

RH132317 (e-PCR)
- UniSTS:215600

px-65a8 (e-PCR)
- UniSTS:258110

STS-H29287 (e-PCR)
- UniSTS:47425

D1Mco66 (e-PCR)
- UniSTS:518483

px-1d6 (e-PCR)
- UniSTS:257381

RH144340 (e-PCR)
- UniSTS:233585

D1Rat418 (e-PCR), detects polymorphism
- UniSTS:227202

RH133190 (e-PCR)
- UniSTS:216473

D1Mgh33 (e-PCR)
- UniSTS:239287

BF406018 (e-PCR)
- UniSTS:248263

BE119877 (e-PCR)
- UniSTS:249291

RH138030 (e-PCR)
- UniSTS:220117

RH144187 (e-PCR)
- UniSTS:233433

BF406149 (e-PCR)
- UniSTS:248287

AU049702 (e-PCR)
- UniSTS:146148

AI073009 (e-PCR)
- UniSTS:261100

BF394251 (e-PCR)
- UniSTS:244729

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in clustering of voltage-gated potassium channels	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuronal ion channel clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde axonal protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in axon initial segment	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	TAS Traceable Author Statement more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disks large homolog 2

Names: channel-associated protein of synapse-110; chapsyn-110; discs, large homolog 2; disks large 1 tumor suppressor protein-like; postsynaptic density protein PSD-93; synaptic density protein PSD-93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022282.2 → NP_071618.2 disks large homolog 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P70548, Q62939, Q63622

UniProtKB/TrEMBL

A6I651, A6I652

Conserved Domains (5) summary

cd12032
Location:534 → 607

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:419 → 497

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:661 → 839

Guanylate_kin; Guanylate kinase

pfam10600
Location:278 → 345

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:14 → 97

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

153864545..155916238

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089312.2 → XP_038945240.1 disks large homolog 2 isoform X1

UniProtKB/TrEMBL

A0A8I6GD69

Conserved Domains (6) summary

cd12032
Location:676 → 749

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:561 → 639

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:835 → 1013

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:420 → 487

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:157 → 239

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089327.2 → XP_038945255.1 disks large homolog 2 isoform X3

UniProtKB/TrEMBL

A0A8I6GD69

Conserved Domains (6) summary

cd12032
Location:676 → 749

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:561 → 639

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:821 → 999

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:420 → 487

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:157 → 239

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089335.2 → XP_038945263.1 disks large homolog 2 isoform X4

UniProtKB/TrEMBL

A0A8I6GD69

Conserved Domains (6) summary

cd12032
Location:676 → 749

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:561 → 639

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:817 → 995

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:420 → 487

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:157 → 239

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089341.2 → XP_038945269.1 disks large homolog 2 isoform X5

UniProtKB/TrEMBL

A0A8I5ZK38, A0A8I6GD69

Related

ENSRNOP00000076548.1, ENSRNOT00000112321.2

Conserved Domains (6) summary

cd12032
Location:676 → 749

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:561 → 639

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:803 → 981

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:420 → 487

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:157 → 239

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089345.2 → XP_038945273.1 disks large homolog 2 isoform X6

UniProtKB/TrEMBL

A0A8I6GD69

Related

ENSRNOP00000107730.1, ENSRNOT00000139981.1

Conserved Domains (6) summary

cd12032
Location:624 → 697

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:509 → 587

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:783 → 961

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:420 → 483

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:157 → 239

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089349.2 → XP_038945277.1 disks large homolog 2 isoform X7

UniProtKB/TrEMBL

A0A8I6GD69

Conserved Domains (6) summary

cd12032
Location:624 → 697

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:509 → 587

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:751 → 929

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:420 → 483

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:157 → 239

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089318.2 → XP_038945246.1 disks large homolog 2 isoform X2

UniProtKB/TrEMBL

A0A8I6GD69

Conserved Domains (6) summary

cd12032
Location:675 → 748

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:560 → 638

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:834 → 1012

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:419 → 486

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:157 → 238

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089424.2 → XP_038945352.1 disks large homolog 2 isoform X29

UniProtKB/TrEMBL

A0A8I6GD69

Conserved Domains (5) summary

cd12032
Location:527 → 600

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:412 → 490

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:686 → 864

Guanylate_kin; Guanylate kinase

pfam10600
Location:271 → 338

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:8 → 90

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_017589651.3 → XP_017445140.1 disks large homolog 2 isoform X10

UniProtKB/TrEMBL

A0A8I6GD69
XM_063272690.1 → XP_063128760.1 disks large homolog 2 isoform X14

UniProtKB/TrEMBL

A0A8I6GD69
XM_063272693.1 → XP_063128763.1 disks large homolog 2 isoform X18

UniProtKB/TrEMBL

A0A8I6G5H5, A0A8I6GD69

Related

ENSRNOP00000079565.1, ENSRNOT00000095796.2
XM_039089369.2 → XP_038945297.1 disks large homolog 2 isoform X12

UniProtKB/TrEMBL

A6I652

Conserved Domains (5) summary

cd12032
Location:554 → 627

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:439 → 517

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:713 → 891

Guanylate_kin; Guanylate kinase

pfam10600
Location:298 → 365

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:36 → 117

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089393.2 → XP_038945321.1 disks large homolog 2 isoform X17

UniProtKB/TrEMBL

A6I652

Conserved Domains (5) summary

cd12032
Location:533 → 606

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:418 → 496

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:692 → 870

Guanylate_kin; Guanylate kinase

pfam10600
Location:277 → 344

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:14 → 96

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_008759648.4 → XP_008757870.1 disks large homolog 2 isoform X16

UniProtKB/TrEMBL

A6I652

Conserved Domains (6) summary

cd12032
Location:534 → 607

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

smart00072
Location:704 → 871

GuKc; Guanylate kinase homologues

cd00992
Location:419 → 497

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:693 → 871

Guanylate_kin; Guanylate kinase

pfam10600
Location:278 → 345

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:14 → 97

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_063272712.1 → XP_063128782.1 disks large homolog 2 isoform X26

UniProtKB/TrEMBL

A6I652
XM_017589652.3 → XP_017445141.1 disks large homolog 2 isoform X11

UniProtKB/TrEMBL

A0A8I6GD69
XM_063272689.1 → XP_063128759.1 disks large homolog 2 isoform X13

UniProtKB/TrEMBL

A0A8I6GD69
XM_063272699.1 → XP_063128769.1 disks large homolog 2 isoform X19

UniProtKB/TrEMBL

A0A8I6GD69

Related

ENSRNOP00000085363.1, ENSRNOT00000103147.2
XM_039089419.2 → XP_038945347.1 disks large homolog 2 isoform X25

UniProtKB/TrEMBL

F1M907

Conserved Domains (5) summary

cd12032
Location:492 → 565

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:377 → 455

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:619 → 797

Guanylate_kin; Guanylate kinase

pfam10600
Location:236 → 303

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:24 → 55

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_063272713.1 → XP_063128783.1 disks large homolog 2 isoform X27

UniProtKB/TrEMBL

A0A8I6ABF7
XM_017589654.3 → XP_017445143.1 disks large homolog 2 isoform X22

UniProtKB/TrEMBL

F1M907
XM_039089356.2 → XP_038945284.1 disks large homolog 2 isoform X8

UniProtKB/TrEMBL

A0A8I5ZMA3, A0A8I6APM7

Related

ENSRNOP00000078924.1, ENSRNOT00000106839.2

Conserved Domains (5) summary

cd12032
Location:569 → 642

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:454 → 532

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:728 → 906

Guanylate_kin; Guanylate kinase

pfam10600
Location:313 → 380

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:45 → 132

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089403.2 → XP_038945331.1 disks large homolog 2 isoform X21

UniProtKB/TrEMBL

A0A8I6APM7

Conserved Domains (5) summary

cd12032
Location:517 → 590

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:402 → 480

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:662 → 840

Guanylate_kin; Guanylate kinase

pfam10600
Location:313 → 376

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:45 → 132

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089365.2 → XP_038945293.1 disks large homolog 2 isoform X9

UniProtKB/TrEMBL

A0A8I6APM7

Conserved Domains (5) summary

cd12032
Location:569 → 642

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:454 → 532

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:714 → 892

Guanylate_kin; Guanylate kinase

pfam10600
Location:313 → 380

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:45 → 132

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089414.2 → XP_038945342.1 disks large homolog 2 isoform X23

UniProtKB/TrEMBL

A0A8I6APM7

Conserved Domains (5) summary

cd12032
Location:517 → 590

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:402 → 480

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:644 → 822

Guanylate_kin; Guanylate kinase

pfam10600
Location:313 → 376

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:45 → 132

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089384.2 → XP_038945312.1 disks large homolog 2 isoform X15

UniProtKB/TrEMBL

A0A8I6APM7, A6I654

Related

ENSRNOP00000096630.1, ENSRNOT00000115131.2

Conserved Domains (5) summary

cd12032
Location:569 → 642

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:454 → 532

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:696 → 874

Guanylate_kin; Guanylate kinase

pfam10600
Location:313 → 380

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:45 → 132

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_017589653.3 → XP_017445142.1 disks large homolog 2 isoform X20

UniProtKB/TrEMBL

A0A8I6ABF7
XM_017589656.3 → XP_017445145.1 disks large homolog 2 isoform X28

UniProtKB/TrEMBL

A0A8I6ABF7
XM_039089416.2 → XP_038945344.1 disks large homolog 2 isoform X24

UniProtKB/TrEMBL

A0A8I6ABF7, A6I655

Conserved Domains (5) summary

cd12032
Location:507 → 580

SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2

cd00992
Location:392 → 470

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:634 → 812

Guanylate_kin; Guanylate kinase

pfam10600
Location:251 → 318

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:42 → 70

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039089431.2 → XP_038945359.1 disks large homolog 2 isoform X30

Conserved Domains (3) summary

cd00992
Location:1 → 29

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:225 → 403

Guanylate_kin; Guanylate kinase

cl17036
Location:66 → 139

SH3; Src Homology 3 domain superfamily
XM_017589655.3 → XP_017445144.1 disks large homolog 2 isoform X31

Conserved Domains (2) summary

pfam00625
Location:175 → 353

Guanylate_kin; Guanylate kinase

cl17036
Location:16 → 89

SH3; Src Homology 3 domain superfamily
XM_063272724.1 → XP_063128794.1 disks large homolog 2 isoform X32
XM_063272726.1 → XP_063128796.1 disks large homolog 2 isoform X33
XM_008759649.4 → XP_008757871.1 disks large homolog 2 isoform X31

Conserved Domains (2) summary

pfam00625
Location:175 → 353

Guanylate_kin; Guanylate kinase

cl17036
Location:16 → 89

SH3; Src Homology 3 domain superfamily
XM_063272725.1 → XP_063128795.1 disks large homolog 2 isoform X32