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    Stxbp4 syntaxin binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stxbp4provided by RGD
    Official Full Name
    syntaxin binding protein 4provided by RGD
    Primary source
    RGD:1307903
    See related
    EnsemblRapid:ENSRNOG00000032768 AllianceGenome:RGD:1307903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable syntaxin binding activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; positive regulation of keratinocyte proliferation; and protein stabilization. Predicted to act upstream of or within cellular response to type II interferon; protein targeting; and regulation of D-glucose transmembrane transport. Predicted to be located in phagocytic vesicle. Predicted to be active in cytoplasmic vesicle. Orthologous to human STXBP4 (syntaxin binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 132.6), Adrenal (RPKM 57.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stxbp4 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (75798938..75955817, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (75301868..75458741, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (78005745..78168641, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480636 Neighboring gene uncharacterized LOC134480711 Neighboring gene uncharacterized LOC134480712 Neighboring gene cytochrome c oxidase copper chaperone COX11 Neighboring gene target of myb1 like 1 membrane trafficking protein Neighboring gene target of myb1 like 3 membrane trafficking protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Li Y, et al. Mol Cell Biol, 2009 Jul. PMID 19451233, Free PMC Article
    2. Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell. Saito T, et al. J Biol Chem, 2003 Sep 19. PMID 12855681
    3. GLUT4 translocation: the last 200 nanometers. Watson RT, et al. Cell Signal, 2007 Nov. PMID 17629673
    4. Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Min J, et al. Mol Cell, 1999 Jun. PMID 10394363
    5. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415095.1 → NP_001402024.1  syntaxin-binding protein 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JXI5, A6HI15, D3Z9G8
      Related
      ENSRNOP00000104784.1, ENSRNOT00000128106.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      75798938..75955817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269103.1 → XP_063125173.1  syntaxin-binding protein 4 isoform X2

      UniProtKB/TrEMBL
      A6HI15, D3Z9G8
      Related
      ENSRNOP00000100226.1, ENSRNOT00000100254.2

    2. XM_063269102.1 → XP_063125172.1  syntaxin-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXI5, A6HI15, D3Z9G8

    3. XM_063269105.1 → XP_063125175.1  syntaxin-binding protein 4 isoform X5

      UniProtKB/TrEMBL
      A6HI15, D3Z9G8

    4. XM_039086053.2 → XP_038941981.1  syntaxin-binding protein 4 isoform X4

      UniProtKB/TrEMBL
      A6HI15, D3Z9G8
      Related
      ENSRNOP00000070285.2, ENSRNOT00000083009.3
      Conserved Domains (2) summary
      COG1196
      Location:304 → 444
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00992
      Location:21 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    5. XM_063269104.1 → XP_063125174.1  syntaxin-binding protein 4 isoform X3

    6. XM_006247131.5 → XP_006247193.1  syntaxin-binding protein 4 isoform X3

      Related
      ENSRNOP00000108577.1, ENSRNOT00000134372.1
      Conserved Domains (4) summary
      cd00992
      Location:21 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam07926
      Location:299 → 400
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cd16269
      Location:359 → 369
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:306 → 389
      GBP_C; Guanylate-binding protein, C-terminal domain

    7. XM_039086054.2 → XP_038941982.1  syntaxin-binding protein 4 isoform X6

      Conserved Domains (1) summary
      cd00992
      Location:21 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RNA

    1. XR_005489844.1 RNA Sequence

    2. XR_005489842.1 RNA Sequence

    3. XR_005489848.2 RNA Sequence

    4. XR_005489846.2 RNA Sequence

    5. XR_005489845.1 RNA Sequence

    6. XR_005489843.1 RNA Sequence

    7. XR_005489850.2 RNA Sequence

    8. XR_005489849.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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