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    Srcin1 SRC kinase signaling inhibitor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srcin1provided by RGD
    Official Full Name
    SRC kinase signaling inhibitor 1provided by RGD
    Primary source
    RGD:708439
    See related
    EnsemblRapid:ENSRNOG00000011475 AllianceGenome:RGD:708439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P140; Snip; p140Cap
    Summary
    Enables protein domain specific binding activity. Involved in negative regulation of protein secretion. Located in several cellular components, including filopodium; lamellipodium; and postsynaptic density. Is active in postsynapse and presynapse. Orthologous to human SRCIN1 (SRC kinase signaling inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 68.0), Testes (RPKM 43.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srcin1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82999295..83066359, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82502911..82569882, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85460059..85517671, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 7 Neighboring gene Rho GTPase activating protein 23 Neighboring gene uncharacterized LOC134480864 Neighboring gene uncharacterized LOC102548331 Neighboring gene uncharacterized LOC134480715 Neighboring gene elongin BC and polycomb repressive complex 2 associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation. Damiano L, et al. Oncogene, 2012 Feb 2. PMID 21725361
    2. Localization of multidomain adaptor proteins, p140Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka Long-Evans Tokushima Fatty rats. Yamauchi M, et al. Med Mol Morphol, 2013 Mar. PMID 23325552
    3. p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization. Repetto D, et al. J Neurosci, 2014 Jan 22. PMID 24453341, Free PMC Article
    4. SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. Chin LS, et al. J Biol Chem, 2000 Jan 14. PMID 10625663
    5. MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1. Wang W, et al. Microvasc Res, 2019 May. PMID 30315850

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of miR-150 promoted angiogenesis and proliferation of endothelial progenitor cells by targeting SRCIN1 in vitro and thrombus resolution in vivo.
      Title: MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1.
    2. Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex.
      Title: A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
    3. we here demonstrate that p140Cap is a key element for both learning and synaptic plasticity
      Title: p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization.
    4. Possible involvement of p140Cap in insulin secretion; the reduction of p140Cap might be related to abnormal insulin secretion in diabetes mellitus.
      Title: Localization of multidomain adaptor proteins, p140Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka Long-Evans Tokushima Fatty rats.
    5. Data show that p140Cap suppresses the invasive properties of highly metastatic breast carcinoma cells by inhibiting cortactin-dependent cell motility.
      Title: p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation.
    6. These results suggest that p140Cap is involved in neurotransmitter release, synapse formation/maintenance, and signaling.
      Title: Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in postsynaptic actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SRC kinase signaling inhibitor 1
    Names
    SNAP25-interacting protein
    p130Cas-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393740.2 → NP_001380669.1  SRC kinase signaling inhibitor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AEP4
      Related
      ENSRNOP00000083677.2, ENSRNOT00000108672.2
      Conserved Domains (2) summary
      smart00806
      Location:218 → 289
      AIP3; Actin interacting protein 3
      TIGR02169
      Location:719 → 873
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_001393741.2 → NP_001380670.1  SRC kinase signaling inhibitor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AEP4, A6HIK5
      Related
      ENSRNOP00000099638.1, ENSRNOT00000153078.1
      Conserved Domains (2) summary
      TIGR02169
      Location:720 → 874
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam03915
      Location:219 → 316
      AIP3; Actin interacting protein 3

    3. NM_019378.3 → NP_062251.1  SRC kinase signaling inhibitor 1 isoform 2

      See identical proteins and their annotated locations for NP_062251.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q9QXY2, Q9QXY3
      UniProtKB/TrEMBL
      A0A8I6AEP4, A6HIK6
      Conserved Domains (1) summary
      pfam03915
      Location:219 → 290
      AIP3; Actin interacting protein 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82999295..83066359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269719.1 → XP_063125789.1  SRC kinase signaling inhibitor 1 isoform X13

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    2. XM_063269720.1 → XP_063125790.1  SRC kinase signaling inhibitor 1 isoform X14

      UniProtKB/TrEMBL
      A0A8L2Q7U5
      Related
      ENSRNOP00000016070.6, ENSRNOT00000016070.8

    3. XM_063269708.1 → XP_063125778.1  SRC kinase signaling inhibitor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    4. XM_063269716.1 → XP_063125786.1  SRC kinase signaling inhibitor 1 isoform X10

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    5. XM_063269711.1 → XP_063125781.1  SRC kinase signaling inhibitor 1 isoform X5

      UniProtKB/TrEMBL
      A0A8L2Q7U5
      Related
      ENSRNOP00000102162.1, ENSRNOT00000121767.1

    6. XM_063269714.1 → XP_063125784.1  SRC kinase signaling inhibitor 1 isoform X8

      UniProtKB/TrEMBL
      A0A8L2Q7U5
      Related
      ENSRNOP00000105332.1, ENSRNOT00000166888.1

    7. XM_063269712.1 → XP_063125782.1  SRC kinase signaling inhibitor 1 isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q7U5
      Related
      ENSRNOP00000080321.2, ENSRNOT00000099263.2

    8. XM_063269709.1 → XP_063125779.1  SRC kinase signaling inhibitor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    9. XM_063269710.1 → XP_063125780.1  SRC kinase signaling inhibitor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    10. XM_063269713.1 → XP_063125783.1  SRC kinase signaling inhibitor 1 isoform X7

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    11. XM_063269707.1 → XP_063125777.1  SRC kinase signaling inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    12. XM_063269723.1 → XP_063125793.1  SRC kinase signaling inhibitor 1 isoform X17

      UniProtKB/TrEMBL
      A0A8I6AEP4
      Related
      ENSRNOP00000095793.2, ENSRNOT00000109362.2

    13. XM_063269730.1 → XP_063125800.1  SRC kinase signaling inhibitor 1 isoform X24

      UniProtKB/TrEMBL
      A0A8I6AEP4

    14. XM_063269722.1 → XP_063125792.1  SRC kinase signaling inhibitor 1 isoform X16

      UniProtKB/TrEMBL
      A0A8I6AEP4

    15. XM_063269729.1 → XP_063125799.1  SRC kinase signaling inhibitor 1 isoform X23

      UniProtKB/TrEMBL
      A0A8I6AEP4

    16. XM_063269727.1 → XP_063125797.1  SRC kinase signaling inhibitor 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I6AEP4

    17. XM_063269726.1 → XP_063125796.1  SRC kinase signaling inhibitor 1 isoform X20

      UniProtKB/TrEMBL
      A0A8I6AEP4

    18. XM_063269731.1 → XP_063125801.1  SRC kinase signaling inhibitor 1 isoform X25

      UniProtKB/TrEMBL
      A0A8I6AEP4

    19. XM_063269721.1 → XP_063125791.1  SRC kinase signaling inhibitor 1 isoform X15

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    20. XM_063269717.1 → XP_063125787.1  SRC kinase signaling inhibitor 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZQE0

    21. XM_063269715.1 → XP_063125785.1  SRC kinase signaling inhibitor 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZQE0

    22. XM_063269718.1 → XP_063125788.1  SRC kinase signaling inhibitor 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZQE0
      Related
      ENSRNOP00000104199.1, ENSRNOT00000127145.1

    23. XM_063269725.1 → XP_063125795.1  SRC kinase signaling inhibitor 1 isoform X19

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    24. XM_063269736.1 → XP_063125806.1  SRC kinase signaling inhibitor 1 isoform X29

      UniProtKB/TrEMBL
      A0A8I6AKG9

    25. XM_063269734.1 → XP_063125804.1  SRC kinase signaling inhibitor 1 isoform X27

      UniProtKB/TrEMBL
      A0A8I6AKG9

    26. XM_063269735.1 → XP_063125805.1  SRC kinase signaling inhibitor 1 isoform X28

      UniProtKB/TrEMBL
      A0A8I6AKG9

    27. XM_063269732.1 → XP_063125802.1  SRC kinase signaling inhibitor 1 isoform X26

      UniProtKB/TrEMBL
      A0A8I6AKG9

    28. XM_063269724.1 → XP_063125794.1  SRC kinase signaling inhibitor 1 isoform X18

      UniProtKB/TrEMBL
      A0A8L2Q7U5

    29. XM_063269728.1 → XP_063125798.1  SRC kinase signaling inhibitor 1 isoform X22

      UniProtKB/TrEMBL
      A0A8I6AEP4

    RNA

    1. XR_010055230.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXY2.1 GenPept UniProtKB/Swiss-Prot:Q9QXY2

    Gene LinkOut

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