Pitpnm3 PITPNM family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pitpnm3provided by RGD
Official Full Name: PITPNM family member 3provided by RGD
Primary source: RGD:1308200
See related: EnsemblRapid:ENSRNOG00000008323 AllianceGenome:RGD:1308200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity; phospholipase activity; and receptor tyrosine kinase binding activity. Located in cell body and cell projection. Human ortholog(s) of this gene implicated in cone-rod dystrophy 5. Orthologous to human PITPNM3 (PITPNM family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 66.5), Lung (RPKM 59.2) and 8 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q24

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (57173230..57265186, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (56674697..56766552, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (58618679..58722679, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

AU028104 (e-PCR)
- UniSTS:112655

AI848332 (e-PCR)
- UniSTS:180244

RH137482 (e-PCR)
- UniSTS:219570

RH128893 (e-PCR)
- UniSTS:212201

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid transporter activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in phospholipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: membrane-associated phosphatidylinositol transfer protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430113.1 → NP_001417042.1 membrane-associated phosphatidylinositol transfer protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HGD7, M0RDK4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

57173230..57265186 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087319.2 → XP_038943247.1 membrane-associated phosphatidylinositol transfer protein 3 isoform X1

Related

ENSRNOP00000067705.3, ENSRNOT00000071764.5

Conserved Domains (2) summary

smart00775
Location:739 → 869

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:393 → 593

DDHD; DDHD domain
XM_063270035.1 → XP_063126105.1 membrane-associated phosphatidylinositol transfer protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I5ZTJ8, A6HGD7

Related

ENSRNOP00000081683.1, ENSRNOT00000120205.2
XM_039087320.2 → XP_038943248.1 membrane-associated phosphatidylinositol transfer protein 3 isoform X4

Conserved Domains (2) summary

smart00775
Location:317 → 447

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:2 → 171

DDHD; DDHD domain
XM_063270036.1 → XP_063126106.1 membrane-associated phosphatidylinositol transfer protein 3 isoform X3