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    Mad1l1 mitotic arrest deficient 1 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mad1l1provided by RGD
    Official Full Name
    mitotic arrest deficient 1 like 1provided by RGD
    Primary source
    RGD:1596881
    See related
    EnsemblRapid:ENSRNOG00000001265 AllianceGenome:RGD:1596881
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and kinetochore binding activity. Predicted to be involved in several processes, including attachment of mitotic spindle microtubules to kinetochore; cytoplasmic sequestering of protein; and regulation of mitotic metaphase/anaphase transition. Predicted to act upstream of or within negative regulation of T cell proliferation; regulation of mitotic cell cycle phase transition; and thymus development. Predicted to be located in cytoplasm; mitotic spindle pole; and nucleus. Predicted to be part of MAD1 complex; mitotic spindle assembly checkpoint MAD1-MAD2 complex; and nuclear pore nuclear basket. Predicted to be active in kinetochore; mitotic spindle; and nuclear envelope. Human ortholog(s) of this gene implicated in lymphoma; mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition; and prostate cancer. Orthologous to human MAD1L1 (mitotic arrest deficient 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 132.9), Liver (RPKM 100.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mad1l1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19434782..19744574)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14320892..14630750)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16410083..16721232)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 1 Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene uncharacterized LOC134481158 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 1 Neighboring gene proteasome assembly chaperone 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of Mad1 in T cells leads to reduced thymic cellularity and impaired mitogen-induced proliferation. Rudolph B, et al. Oncogene, 2001 Mar 8. PMID 11313860
    2. Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. Kim S, et al. Proc Natl Acad Sci U S A, 2012 Apr 24. PMID 22493223, Free PMC Article
    3. RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. Yeh PC, et al. J Biol Chem, 2012 Apr 6. PMID 22351768, Free PMC Article
    4. Cytoplasmic dynein participates in meiotic checkpoint inactivation in mouse oocytes by transporting cytoplasmic mitotic arrest-deficient (Mad) proteins from kinetochores to spindle poles. Zhang D, et al. Reproduction, 2007 Apr. PMID 17504913
    5. Expression and subcellular localization of the Myc superfamily proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate cartilage chondrocytes of growing rats. Wang Y, et al. Cell Mol Biol (Noisy-le-grand), 1997 Mar. PMID 9130602

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinetochore binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic sequestering of protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in deactivation of mitotic spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within thymus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MAD1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitotic spindle assembly checkpoint MAD1-MAD2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitotic spindle assembly checkpoint protein MAD1
    Names
    MAD1 mitotic arrest deficient like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109387.1 → NP_001102857.1  mitotic spindle assembly checkpoint protein MAD1

      See identical proteins and their annotated locations for NP_001102857.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474012
      UniProtKB/TrEMBL
      A0A8I6A596, A6K1T2, D3ZIV3
      Conserved Domains (1) summary
      pfam05557
      Location:54 → 715
      MAD; Mitotic checkpoint protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19434782..19744574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271650.1 → XP_063127720.1  mitotic spindle assembly checkpoint protein MAD1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A596
      Related
      ENSRNOP00000087168.2, ENSRNOT00000114435.2

    2. XM_017598453.3 → XP_017453942.1  mitotic spindle assembly checkpoint protein MAD1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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