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    Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hsd17b11provided by RGD
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 11provided by RGD
    Primary source
    RGD:1303235
    See related
    EnsemblRapid:ENSRNOG00000002210 AllianceGenome:RGD:1303235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dhrs8
    Summary
    Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in androgen catabolic process. Predicted to be located in cytoplasm. Predicted to be active in lipid droplet. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1314.4), Kidney (RPKM 343.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hsd17b11 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (5997893..6047816)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5693304..5743157)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7054724..7104567)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SPARC like 1 Neighboring gene secretory calcium-binding phosphoprotein proline-glutamine rich 1 Neighboring gene nudix hydrolase 9 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene uncharacterized LOC120096561 Neighboring gene kelch-like family member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hydroxysteroid 17β-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis. Thomes PG, et al. J Biol Chem, 2023 Apr. PMID 36849008, Free PMC Article
    2. Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily. Keller B, et al. Mol Cell Endocrinol, 2009 Mar 25. PMID 18775470
    3. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. Chai Z, et al. Endocrinology, 2003 May. PMID 12697717
    4. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Fujimoto Y, et al. Biochim Biophys Acta, 2004 Feb 2. PMID 14741744
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hydroxysteroid 17beta-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis.
      Title: Hydroxysteroid 17β-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis.
    2. The localization studies on rat short-chain dehydrogenases/reductases dhrs7b and dhrs8, are shown.
      Title: Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93725

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    estradiol 17-beta-dehydrogenase 11
    Names
    17-beta-HSD 11
    17-beta-HSD XI
    17-beta-hydroxysteroid dehydrogenase 11
    17-beta-hydroxysteroid dehydrogenase XI
    17bHSD11
    17betaHSD11
    17betaHSDXI
    dehydrogenase/reductase SDR family member 8
    NP_001004209.1
    XP_006250689.1
    XP_006250691.1
    XP_063128963.1
    XP_063128964.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004209.1 → NP_001004209.1  estradiol 17-beta-dehydrogenase 11 precursor

      See identical proteins and their annotated locations for NP_001004209.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078929
      UniProtKB/Swiss-Prot
      Q6AYS8
      Conserved Domains (2) summary
      cd05339
      Location:38 → 277
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:37 → 228
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      5997893..6047816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250629.5 → XP_006250691.1  estradiol 17-beta-dehydrogenase 11 isoform X1

      See identical proteins and their annotated locations for XP_006250691.1

      UniProtKB/Swiss-Prot
      Q6AYS8
      Related
      ENSRNOP00000003004.3, ENSRNOT00000003004.8
      Conserved Domains (2) summary
      cd05339
      Location:38 → 277
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:37 → 228
      adh_short; short chain dehydrogenase

    2. XM_063272893.1 → XP_063128963.1  estradiol 17-beta-dehydrogenase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYS8

    3. XM_063272894.1 → XP_063128964.1  estradiol 17-beta-dehydrogenase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYS8

    4. XM_006250627.5 → XP_006250689.1  estradiol 17-beta-dehydrogenase 11 isoform X1

      See identical proteins and their annotated locations for XP_006250689.1

      UniProtKB/Swiss-Prot
      Q6AYS8
      Conserved Domains (2) summary
      cd05339
      Location:38 → 277
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:37 → 228
      adh_short; short chain dehydrogenase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYS8.1 GenPept UniProtKB/Swiss-Prot:Q6AYS8

    Gene LinkOut

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