Tmem175 transmembrane protein 175 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem175provided by RGD
Official Full Name: transmembrane protein 175provided by RGD
Primary source: RGD:1309712
See related: EnsemblRapid:ENSRNOG00000000044 AllianceGenome:RGD:1309712
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309712
Summary: Predicted to enable arachidonate binding activity; potassium ion leak channel activity; and proton channel activity. Predicted to be involved in lysosome organization; monoatomic cation transmembrane transport; and neuron cellular homeostasis. Predicted to be located in endosome membrane and lysosomal membrane. Predicted to be active in endosome and lysosome. Orthologous to human TMEM175 (transmembrane protein 175). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 125.2), Thymus (RPKM 83.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (1217911..1234236, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (1073410..1089764, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (2083745..2100006, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion.
Title: TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion.
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases alpha-synuclein aggregation.
Title: TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.

Submit: New GeneRIF Correction

General gene information

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Markers

BI276490 (e-PCR)
- UniSTS:249868

RH135170 (e-PCR)
- UniSTS:218447

RH129524 (e-PCR)
- UniSTS:212826

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate binding	ISO Inferred from Sequence Orthology more info
enables arachidonate binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables proton channel activity	IEA Inferred from Electronic Annotation more info
enables proton channel activity	ISO Inferred from Sequence Orthology more info
enables proton channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lysosomal lumen pH elevation	ISO Inferred from Sequence Orthology more info
involved_in lysosomal lumen pH elevation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in phagosome-lysosome fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lysosomal lumen pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of lysosomal lumen pH	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endosomal/lysosomal proton channel TMEM175

Names: endosomal/lysomomal potassium channel TMEM175; endosomal/lysosomal potassium channel TMEM175; potassium channel TMEM175

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013991.1 → NP_001014013.1 endosomal/lysosomal proton channel TMEM175

See identical proteins and their annotated locations for NP_001014013.1

Status: PROVISIONAL

Source sequence(s)

BC079245

UniProtKB/Swiss-Prot

Q6AY05

UniProtKB/TrEMBL

A0A8I5ZUF0, A6KPE4

Related

ENSRNOP00000000050.3, ENSRNOT00000000050.8

Conserved Domains (1) summary

pfam06736
Location:257 → 353

DUF1211; Protein of unknown function (DUF1211)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

1217911..1234236 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599261.3 → XP_017454750.1 endosomal/lysosomal proton channel TMEM175 isoform X3

UniProtKB/TrEMBL

A0A8I5ZUF0

Conserved Domains (1) summary

pfam06736
Location:202 → 298

DUF1211; Protein of unknown function (DUF1211)
XM_039092128.2 → XP_038948056.1 endosomal/lysosomal proton channel TMEM175 isoform X2

UniProtKB/TrEMBL

A0A8I5ZUF0

Conserved Domains (1) summary

pfam06736
Location:256 → 352

DUF1211; Protein of unknown function (DUF1211)
XM_063273298.1 → XP_063129368.1 endosomal/lysosomal proton channel TMEM175 isoform X4

UniProtKB/TrEMBL

A0A8I5ZUF0
XM_063273296.1 → XP_063129366.1 endosomal/lysosomal proton channel TMEM175 isoform X2

UniProtKB/TrEMBL

A0A8I5ZUF0
XM_063273297.1 → XP_063129367.1 endosomal/lysosomal proton channel TMEM175 isoform X3

UniProtKB/TrEMBL

A0A8I5ZUF0
XM_006250558.5 → XP_006250620.1 endosomal/lysosomal proton channel TMEM175 isoform X1

See identical proteins and their annotated locations for XP_006250620.1

UniProtKB/Swiss-Prot

Q6AY05

UniProtKB/TrEMBL

A0A8I5ZUF0, A6KPE4

Conserved Domains (1) summary

pfam06736
Location:257 → 353

DUF1211; Protein of unknown function (DUF1211)
XM_017599263.3 → XP_017454752.1 endosomal/lysosomal proton channel TMEM175 isoform X5

UniProtKB/TrEMBL

A0A8I5ZUF0

Conserved Domains (1) summary

pfam06736
Location:178 → 274

DUF1211; Protein of unknown function (DUF1211)
XM_063273301.1 → XP_063129371.1 endosomal/lysosomal proton channel TMEM175 isoform X8
XM_063273300.1 → XP_063129370.1 endosomal/lysosomal proton channel TMEM175 isoform X6
XM_039092130.2 → XP_038948058.1 endosomal/lysosomal proton channel TMEM175 isoform X7

Conserved Domains (1) summary

pfam06736
Location:105 → 201

DUF1211; Protein of unknown function (DUF1211)