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    Zmiz1 zinc finger, MIZ-type containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361103, updated on 9-Dec-2024

    Summary

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    Symbol
    Zmiz1provided by RGD
    Full Name
    zinc finger, MIZ-type containing 1provided by RGD
    Primary source
    RGD:1311620
    See related
    EnsemblRapid:ENSRNOG00000010488 AllianceGenome:RGD:1311620
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rai17
    Summary
    Predicted to enable SMAD binding activity; SUMO ligase activity; and nuclear receptor coactivator activity. Predicted to be involved in several processes, including androgen receptor signaling pathway; cell surface receptor protein serine/threonine kinase signaling pathway; and positive regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including circulatory system development; positive regulation of fibroblast proliferation; and vitellogenesis. Predicted to be located in chromatin; cytosol; and nucleoplasm. Orthologous to human ZMIZ1 (zinc finger MIZ-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 75.6), Lung (RPKM 41.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zmiz1 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (1033983..1239425)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (1027083..1232616)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (1749191..1954633)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482436 Neighboring gene uncharacterized LOC120097507 Neighboring gene microRNA 3075 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene peptidylprolyl isomerase F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZMIZ1 Variants Cause a Syndromic Neurodevelopmental Disorder. Carapito R, et al. Am J Hum Genet, 2019 Feb 7. PMID 30639322, Free PMC Article
    2. hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. Sharma M, et al. EMBO J, 2003 Nov 17. PMID 14609956, Free PMC Article
    3. The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Beliakoff J, et al. Mol Cell Biol, 2008 Jan. PMID 17967885, Free PMC Article
    4. Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Tarunina M, et al. Mol Cell Biol, 2004 Dec. PMID 15572682, Free PMC Article
    5. The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. Li X, et al. J Biol Chem, 2006 Aug 18. PMID 16777850

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within developmental growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyramidal neuron migration to cerebral cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vitellogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MIZ domain-containing protein 1
    Names
    retinoic acid induced 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108393.1 → NP_001101863.1  zinc finger MIZ domain-containing protein 1

      See identical proteins and their annotated locations for NP_001101863.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474067
      UniProtKB/TrEMBL
      A6KMH0, D4AE97
      Related
      ENSRNOP00000014003.5, ENSRNOT00000014004.9
      Conserved Domains (3) summary
      PHA03247
      Location:183 → 562
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:746 → 793
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
      pfam18028
      Location:8 → 100
      Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      1033983..1239425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275487.1 → XP_063131557.1  zinc finger MIZ domain-containing protein 1 isoform X4

      Related
      ENSRNOP00000082013.2, ENSRNOT00000101223.2

    2. XM_063275482.1 → XP_063131552.1  zinc finger MIZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KMH0, D4AE97

    3. XM_063275484.1 → XP_063131554.1  zinc finger MIZ domain-containing protein 1 isoform X2

    4. XM_006252539.5 → XP_006252601.1  zinc finger MIZ domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZU59
      Conserved Domains (2) summary
      pfam02891
      Location:745 → 793
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam04487
      Location:325 → 450
      CITED; CITED

    5. XM_006252538.5 → XP_006252600.1  zinc finger MIZ domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam02891
      Location:739 → 787
      zf-MIZ; MIZ/SP-RING zinc finger

    6. XM_063275483.1 → XP_063131553.1  zinc finger MIZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KMH0, D4AE97

    7. XM_063275481.1 → XP_063131551.1  zinc finger MIZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KMH0, D4AE97

    8. XM_063275485.1 → XP_063131555.1  zinc finger MIZ domain-containing protein 1 isoform X2

    9. XM_063275488.1 → XP_063131558.1  zinc finger MIZ domain-containing protein 1 isoform X4

    10. XM_039094612.2 → XP_038950540.1  zinc finger MIZ domain-containing protein 1 isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:59 → 438
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:622 → 669
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    11. XM_039094611.2 → XP_038950539.1  zinc finger MIZ domain-containing protein 1 isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:59 → 438
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:622 → 669
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    12. XM_017600163.3 → XP_017455652.1  zinc finger MIZ domain-containing protein 1 isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:59 → 438
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:622 → 669
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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