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    Cesl1 carboxylesterase-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cesl1provided by RGD
    Official Full Name
    carboxylesterase-like 1provided by RGD
    Primary source
    RGD:1565666
    See related
    EnsemblRapid:ENSRNOG00000079343 AllianceGenome:RGD:1565666
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable carboxylesterase activity. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Cesl1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (38554365..38612663, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (22670709..23006329, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1E-like Neighboring gene KH homology domain-containing protein 1-like Neighboring gene disks large homolog 5-like Neighboring gene zinc finger CCCH-type containing, antiviral 1, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rat kidney carboxylesterase. Cloning, sequencing, cellular localization, and relationship to rat liver hydrolase. Yan B, et al. J Biol Chem, 1994 Nov 25. PMID 7961958
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    liver carboxylesterase B-1
    Names
    liver microsomal carboxylesterase
    NP_001019536.1
    XP_038953872.1
    XP_038953873.1
    XP_063134329.1
    XP_063134330.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024365.1 → NP_001019536.1  liver carboxylesterase B-1 precursor

      See identical proteins and their annotated locations for NP_001019536.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079129
      UniProtKB/Swiss-Prot
      Q63010, Q6AYA3, Q9QUX6
      UniProtKB/TrEMBL
      F1LLV6, M0R7R1
      Related
      ENSRNOP00000065493.3, ENSRNOT00000074070.4
      Conserved Domains (2) summary
      COG0657
      Location:121 → 234
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:24 → 545
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      38554365..38612663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278260.1 → XP_063134330.1  liver carboxylesterase B-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AQM1

    2. XM_063278259.1 → XP_063134329.1  liver carboxylesterase B-1 isoform X1

      UniProtKB/Swiss-Prot
      Q63010, Q6AYA3, Q9QUX6
      UniProtKB/TrEMBL
      F1LLV6

    3. XM_039097945.2 → XP_038953873.1  liver carboxylesterase B-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7X1
      Related
      ENSRNOP00000087408.2, ENSRNOT00000105831.2
      Conserved Domains (1) summary
      pfam00135
      Location:14 → 537
      COesterase; Carboxylesterase family

    4. XM_039097944.1 → XP_038953872.1  liver carboxylesterase B-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7X1
      Conserved Domains (1) summary
      pfam00135
      Location:14 → 537
      COesterase; Carboxylesterase family

    RNA

    1. XR_010060021.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63010.1 GenPept UniProtKB/Swiss-Prot:Q63010

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