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    Tmod4 tropomodulin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmod4provided by RGD
    Official Full Name
    tropomodulin 4provided by RGD
    Primary source
    RGD:1308940
    See related
    EnsemblRapid:ENSRNOG00000021088 AllianceGenome:RGD:1308940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to be active in striated muscle thin filament. Orthologous to human TMOD4 (tropomodulin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 2345.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmod4 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185384547..185389549)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182695709..182700540)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196294990..196299896)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha Neighboring gene vacuolar protein sorting 72 homolog Neighboring gene sodium channel modifier 1 Neighboring gene LysM domain containing 1 Neighboring gene TNF alpha induced protein 8 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy. Yuen M, et al. J Clin Invest, 2014 Nov. PMID 25250574, Free PMC Article
    2. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. Gokhin DS, et al. J Cell Biol, 2010 Apr 5. PMID 20368620, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tropomyosin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pointed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle thin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tropomodulin-4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106449.2 → NP_001099919.1  tropomodulin-4

      See identical proteins and their annotated locations for NP_001099919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      FM111895, FN800735, JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3
      Conserved Domains (2) summary
      pfam03250
      Location:4 → 143
      Tropomodulin
      cl39015
      Location:184 → 286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. NM_001270650.1 → NP_001257579.1  tropomodulin-4

      See identical proteins and their annotated locations for NP_001257579.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      FM111895, FN800735, JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3
      Conserved Domains (2) summary
      pfam03250
      Location:4 → 143
      Tropomodulin
      cl39015
      Location:184 → 286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. NM_001270651.1 → NP_001257580.1  tropomodulin-4

      See identical proteins and their annotated locations for NP_001257580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      FM111895, FN800735, JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3
      Conserved Domains (2) summary
      pfam03250
      Location:4 → 143
      Tropomodulin
      cl39015
      Location:184 → 286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. NM_001270652.1 → NP_001257581.1  tropomodulin-4

      See identical proteins and their annotated locations for NP_001257581.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      FM111895, FN800735, JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3
      Conserved Domains (2) summary
      pfam03250
      Location:4 → 143
      Tropomodulin
      cl39015
      Location:184 → 286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    5. NM_001270653.1 → NP_001257582.1  tropomodulin-4

      See identical proteins and their annotated locations for NP_001257582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      FM111895, FN800735, JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3
      Conserved Domains (2) summary
      pfam03250
      Location:4 → 143
      Tropomodulin
      cl39015
      Location:184 → 286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185384547..185389549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281624.1 → XP_063137694.1  tropomodulin-4 isoform X1

      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3

    2. XM_063281621.1 → XP_063137691.1  tropomodulin-4 isoform X1

      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3

    3. XM_063281619.1 → XP_063137689.1  tropomodulin-4 isoform X1

      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3

    4. XM_063281618.1 → XP_063137688.1  tropomodulin-4 isoform X1

      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3

    5. XM_063281622.1 → XP_063137692.1  tropomodulin-4 isoform X1

      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3

    6. XM_063281625.1 → XP_063137695.1  tropomodulin-4 isoform X1

      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3

    7. XM_063281623.1 → XP_063137693.1  tropomodulin-4 isoform X1

      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3

    8. XM_063281620.1 → XP_063137690.1  tropomodulin-4 isoform X1

      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3

    9. XM_039102047.2 → XP_038957975.1  tropomodulin-4 isoform X1

      UniProtKB/TrEMBL
      A6K2U7, D3ZSG3
      Related
      ENSRNOP00000074417.1, ENSRNOT00000088312.3
      Conserved Domains (2) summary
      pfam03250
      Location:4 → 143
      Tropomodulin
      cl39015
      Location:184 → 286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    Nucleotide Protein Strain
    Heading Accession and Version

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