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    Cep85l centrosomal protein 85-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100365935, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep85lprovided by RGD
    Official Full Name
    centrosomal protein 85-likeprovided by RGD
    Primary source
    RGD:2319745
    See related
    EnsemblRapid:ENSRNOG00000000414 AllianceGenome:RGD:2319745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in neuron migration. Predicted to be located in pericentriolar material. Predicted to be active in centrosome. Human ortholog(s) of this gene implicated in lissencephaly 10. Orthologous to human CEP85L (centrosomal protein 85 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 123.3), Muscle (RPKM 115.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep85l in Genome Data Viewer
    Location:
    20q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (33111114..33282182, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (32568417..32739449, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (34574043..34743142, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member F1 Neighboring gene uncharacterized LOC120098878 Neighboring gene uncharacterized LOC134483813 Neighboring gene phospholamban Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 9 Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene minichromosome maintenance 9 homologous recombination repair factor like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 85 kDa-like
    Names
    rCG22129-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177829.2 → NP_001171300.1  centrosomal protein of 85 kDa-like

      See identical proteins and their annotated locations for NP_001171300.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6K489, B1H279, F7EXF4
      Related
      ENSRNOP00000070599.3, ENSRNOT00000078420.3
      Conserved Domains (1) summary
      cl23887
      Location:510 → 657
      DUF4349; Domain of unknown function (DUF4349)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      33111114..33282182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278909.1 → XP_063134979.1  centrosomal protein of 85 kDa-like isoform X4

      UniProtKB/TrEMBL
      B1H279
      Related
      ENSRNOP00000072010.3, ENSRNOT00000087220.3

    2. XM_017601525.3 → XP_017457014.1  centrosomal protein of 85 kDa-like isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1W5, B1H279

    3. XM_017601526.3 → XP_017457015.1  centrosomal protein of 85 kDa-like isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1W5, B1H279

    4. XM_017601524.3 → XP_017457013.1  centrosomal protein of 85 kDa-like isoform X1

      UniProtKB/TrEMBL
      B1H279
      Related
      ENSRNOP00000058939.3, ENSRNOT00000063920.5

    5. XM_063278910.1 → XP_063134980.1  centrosomal protein of 85 kDa-like isoform X5

      UniProtKB/TrEMBL
      B1H279
      Related
      ENSRNOP00000104931.1, ENSRNOT00000122022.1

    6. XM_039098358.1 → XP_038954286.1  centrosomal protein of 85 kDa-like isoform X3

      UniProtKB/TrEMBL
      B1H279
      Conserved Domains (1) summary
      COG1196
      Location:421 → 657
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_063278912.1 → XP_063134982.1  centrosomal protein of 85 kDa-like isoform X7

    8. XM_063278911.1 → XP_063134981.1  centrosomal protein of 85 kDa-like isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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