Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkag2provided by RGD
Official Full Name: protein kinase AMP-activated non-catalytic subunit gamma 2provided by RGD
Primary source: RGD:727782
See related: EnsemblRapid:ENSRNOG00000009085 AllianceGenome:RGD:727782
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables AMP binding activity and protein kinase binding activity. Contributes to AMP-activated protein kinase activity. Involved in regulation of catalytic activity. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 35.3), Brain (RPKM 28.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (10744695..10985939)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (10010890..10252155)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (6559153..6799888)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overall, however, the results from both experimental models support a scenario in which AICAR directly represses protein synthesis and mTOR signaling in the liver through an AMPK-dependent mechanism.
Title: Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside.
results indicate that ischemia activates catalytic alpha1 and alpha2 isoforms similarly in gamma1 and gamma2 isoform-containing AMPK complexes and that gamma1-isoform complexes account for most of the AMPK activity in the ischemic heart
Title: Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140415 (e-PCR)
- UniSTS:222490

d4mgh23 (e-PCR)
- UniSTS:120433

AI854673 (e-PCR)
- UniSTS:179133

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables AMP binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to AMP-activated protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to AMP-activated protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables phosphorylase kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of carbon utilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glycolytic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-activated protein kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5'-AMP-activated protein kinase subunit gamma-2

Names: AMP-activated protein kinase gamma2 subunit; AMPK gamma 2; adenosine monophosphate-activated protein kinase gamma 2-subunit; protein kinase, AMP-activated, gamma 2 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398879.1 → NP_001385808.1 5'-AMP-activated protein kinase subunit gamma-2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I5Y6F6

Conserved Domains (2) summary

cd04618
Location:266 → 403

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:429 → 552

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
NM_184051.1 → NP_908940.1 5'-AMP-activated protein kinase subunit gamma-2 isoform 2

See identical proteins and their annotated locations for NP_908940.1

Status: PROVISIONAL

Source sequence(s)

AY348865

UniProtKB/TrEMBL

A6KJH6, F1LM70, Q6V7V4

Conserved Domains (3) summary

COG0517
Location:192 → 308

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:35 → 164

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:191 → 310

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

10744695..10985939

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235951.4 → XP_006236013.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X5

UniProtKB/TrEMBL

A0A140UHX4, A0A8I5Y6F6

Related

ENSRNOP00000062361.4, ENSRNOT00000067183.5

Conserved Domains (3) summary

COG0517
Location:433 → 549

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:276 → 405

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:432 → 551

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
XM_063286390.1 → XP_063142460.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X8

UniProtKB/TrEMBL

Q4QRB9
XM_063286391.1 → XP_063142461.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X9

UniProtKB/TrEMBL

Q4QRB9
XM_006235949.4 → XP_006236011.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X3

UniProtKB/TrEMBL

A0A8I5Y6F6

Conserved Domains (3) summary

COG0517
Location:433 → 549

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:276 → 405

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:432 → 551

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
XM_063286389.1 → XP_063142459.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X4

UniProtKB/TrEMBL

A0A8I5Y6F6
XM_017592729.3 → XP_017448218.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X1

UniProtKB/TrEMBL

A0A8I5Y6F6
XM_017592730.3 → XP_017448219.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X2

UniProtKB/TrEMBL

A0A8I5Y6F6
XM_039107960.2 → XP_038963888.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X7

UniProtKB/TrEMBL

A0A8I5Y6F6

Conserved Domains (2) summary

cd04618
Location:218 → 355

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:381 → 479

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
XM_017592731.3 → XP_017448220.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X6

UniProtKB/TrEMBL

A0A8I5Y6F6
XM_039107963.2 → XP_038963891.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X12

UniProtKB/TrEMBL

Q4QRB9

Conserved Domains (2) summary

cd04618
Location:115 → 252

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:278 → 376

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
XM_017592732.3 → XP_017448221.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X10
XM_063286392.1 → XP_063142462.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X11

UniProtKB/TrEMBL

Q4QRB9
XM_006235955.5 → XP_006236017.2 5'-AMP-activated protein kinase subunit gamma-2 isoform X13

UniProtKB/TrEMBL

A0A8I5ZQR3, Q4QRB9

Related

ENSRNOP00000080463.1, ENSRNOT00000106083.2
XM_063286393.1 → XP_063142463.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X14

UniProtKB/TrEMBL

Q4QRB9
XM_063286396.1 → XP_063142466.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X17

UniProtKB/TrEMBL

A6KJH6
XM_063286398.1 → XP_063142468.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X21

UniProtKB/TrEMBL

A6KJH6, F1LM70, Q6V7V4
XM_063286394.1 → XP_063142464.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X15
XM_063286395.1 → XP_063142465.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X16
XM_063286397.1 → XP_063142467.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X20

UniProtKB/TrEMBL

A6KJH6
XM_063286399.1 → XP_063142469.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X22

UniProtKB/TrEMBL

A6KJH6
XM_063286400.1 → XP_063142470.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X23

UniProtKB/TrEMBL

A6KJH6
XM_039107964.2 → XP_038963892.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X18

Conserved Domains (2) summary

cd04618
Location:25 → 162

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:188 → 286

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
XM_039107965.2 → XP_038963893.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X19

Conserved Domains (2) summary

cd04618
Location:24 → 161

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:187 → 285

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase