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    Plag1 PLAG1 zinc finger [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297804, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plag1provided by RGD
    Official Full Name
    PLAG1 zinc fingerprovided by RGD
    Primary source
    RGD:1305286
    See related
    EnsemblRapid:ENSRNOG00000008846 AllianceGenome:RGD:1305286
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of glial cell proliferation and regulation of gene expression. Predicted to act upstream of or within gland morphogenesis and prostate gland growth. Predicted to be located in centrosome; cytosol; and nuclear speck. Human ortholog(s) of this gene implicated in Silver-Russell syndrome and pleomorphic adenoma. Orthologous to human PLAG1 (PLAG1 zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 55.5), Thymus (RPKM 48.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plag1 in Genome Data Viewer
    Location:
    5q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (21699650..21754325, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (16902057..16956727, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (16788186..16842827, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene ribosomal protein L19 like 4 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 7 Neighboring gene short chain dehydrogenase/reductase family 16C, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/β-Catenin Signalling Pathway. Gu Q, et al. Folia Biol (Praha), 2022. PMID 36201855
    2. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Voz ML, et al. Cancer Res, 2000 Jan 1. PMID 10646861
    3. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. Aström AK, et al. Cancer Res, 1999 Feb 15. PMID 10029085
    4. Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Hide T, et al. Cancer Res, 2009 Oct 15. PMID 19808959
    5. Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility. Hensen K, et al. Dev Growth Differ, 2004 Oct. PMID 15606491

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/beta-Catenin Signalling Pathway.
      Title: PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/β-Catenin Signalling Pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94626

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within organ growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within prostate gland growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein PLAG1
    Names
    pleiomorphic adenoma gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008316.2 → NP_001008317.1  zinc finger protein PLAG1

      See identical proteins and their annotated locations for NP_001008317.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q5U2T6
      UniProtKB/TrEMBL
      A6JFM0
      Related
      ENSRNOP00000011721.3, ENSRNOT00000011721.6
      Conserved Domains (3) summary
      COG5189
      Location:58 → 139
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:79 → 103
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      21699650..21754325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763525.4 → XP_008761747.1  zinc finger protein PLAG1 isoform X1

      See identical proteins and their annotated locations for XP_008761747.1

      UniProtKB/Swiss-Prot
      Q5U2T6
      UniProtKB/TrEMBL
      A6JFM0
      Conserved Domains (3) summary
      COG5189
      Location:58 → 139
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:79 → 103
      zf-H2C2_2; Zinc-finger double domain

    2. XM_063287277.1 → XP_063143347.1  zinc finger protein PLAG1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2T6
      UniProtKB/TrEMBL
      A6JFM0

    3. XM_063287274.1 → XP_063143344.1  zinc finger protein PLAG1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2T6
      UniProtKB/TrEMBL
      A6JFM0

    4. XM_063287275.1 → XP_063143345.1  zinc finger protein PLAG1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2T6
      UniProtKB/TrEMBL
      A6JFM0

    5. XM_017593224.3 → XP_017448713.1  zinc finger protein PLAG1 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:70 → 90
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:10 → 58
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    6. XM_063287278.1 → XP_063143348.1  zinc finger protein PLAG1 isoform X2

    7. XM_063287276.1 → XP_063143346.1  zinc finger protein PLAG1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2T6
      UniProtKB/TrEMBL
      A6JFM0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2T6.1 GenPept UniProtKB/Swiss-Prot:Q5U2T6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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