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    Dync2i1 dynein 2 intermediate chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314523, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dync2i1provided by RGD
    Official Full Name
    dynein 2 intermediate chain 1provided by RGD
    Primary source
    RGD:1306493
    See related
    EnsemblRapid:ENSRNOG00000004520 AllianceGenome:RGD:1306493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr60; RGD1306493
    Summary
    Predicted to enable dynein light chain binding activity. Predicted to be involved in cilium assembly; embryonic skeletal system morphogenesis; and intraciliary retrograde transport. Predicted to be located in ciliary base and microtubule cytoskeleton. Predicted to be part of cytoplasmic dynein complex. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 153.2), Lung (RPKM 62.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dync2i1 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143276441..143333006, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (137133418..137189937, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (144069077..144124975, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene chromatin target of PRMT1, pseudogene 1 Neighboring gene uncharacterized LOC134479489 Neighboring gene extended synaptotagmin 2 Neighboring gene ribosomal protein L32, pseudogene 17 Neighboring gene uncharacterized LOC134479490

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Short-rib polydactyly and Jeune syndromes are caused by mutations in WDR60. McInerney-Leo AM, et al. Am J Hum Genet, 2013 Sep 5. PMID 23910462, Free PMC Article
    2. Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis. Gholkar AA, et al. Cell Cycle, 2015. PMID 25830415, Free PMC Article
    3. Subunit composition of the human cytoplasmic dynein-2 complex. Asante D, et al. J Cell Sci, 2014 Nov 1. PMID 25205765, Free PMC Article
    4. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article
    5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein heavy chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary retrograde transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in interphase microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic dynein 2 intermediate chain 1
    Names
    WD repeat domain 60
    WD repeat-containing protein 60

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191773.2 → NP_001178702.1  cytoplasmic dynein 2 intermediate chain 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5YCM7, A0A8I5ZSL7
      Related
      ENSRNOP00000078104.1, ENSRNOT00000099487.2
      Conserved Domains (4) summary
      COG2319
      Location:574 → 970
      WD40; WD40 repeat [General function prediction only]
      pfam12871
      Location:53 → 132
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      sd00039
      Location:646 → 675
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:643 → 931
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001433993.1 → NP_001420922.1  cytoplasmic dynein 2 intermediate chain 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZSL7

    3. NM_001433994.1 → NP_001420923.1  cytoplasmic dynein 2 intermediate chain 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZSL7, A0A8I5ZWP7

    4. NM_001433995.1 → NP_001420924.1  cytoplasmic dynein 2 intermediate chain 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZSL7

    5. NM_001433996.1 → NP_001420925.1  cytoplasmic dynein 2 intermediate chain 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZSL7

    6. NM_001433997.1 → NP_001420926.1  cytoplasmic dynein 2 intermediate chain 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZSL7

    7. NM_001433998.1 → NP_001420927.1  cytoplasmic dynein 2 intermediate chain 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZSL7

    8. NM_001433999.1 → NP_001420928.1  cytoplasmic dynein 2 intermediate chain 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZSL7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      143276441..143333006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112430.2 → XP_038968358.2  cytoplasmic dynein 2 intermediate chain 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZSL7
      Related
      ENSRNOP00000006144.7, ENSRNOT00000006144.8

    2. XM_017594198.3 → XP_017449687.1  cytoplasmic dynein 2 intermediate chain 1 isoform X7

      Conserved Domains (3) summary
      PTZ00121
      Location:16 → 356
      PTZ00121; MAEBL; Provisional
      COG2319
      Location:534 → 930
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:606 → 635
      7WD40; WD40 repeat [structural motif]

    3. XM_039112429.2 → XP_038968357.1  cytoplasmic dynein 2 intermediate chain 1 isoform X7

      Conserved Domains (3) summary
      PTZ00121
      Location:16 → 356
      PTZ00121; MAEBL; Provisional
      COG2319
      Location:534 → 930
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:606 → 635
      7WD40; WD40 repeat [structural motif]

    4. XM_039112428.2 → XP_038968356.1  cytoplasmic dynein 2 intermediate chain 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K1X3, A0A8I5ZSL7
      Conserved Domains (3) summary
      PTZ00121
      Location:5 → 395
      PTZ00121; MAEBL; Provisional
      COG2319
      Location:574 → 970
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:646 → 675
      7WD40; WD40 repeat [structural motif]

    5. XM_017594195.3 → XP_017449684.1  cytoplasmic dynein 2 intermediate chain 1 isoform X6

      Related
      ENSRNOP00000083494.1, ENSRNOT00000109958.2

    6. XM_017594193.3 → XP_017449682.1  cytoplasmic dynein 2 intermediate chain 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSL7
      Related
      ENSRNOP00000080236.2, ENSRNOT00000093919.2

    7. XM_006240688.5 → XP_006240750.1  cytoplasmic dynein 2 intermediate chain 1 isoform X1

      Related
      ENSRNOP00000072019.3, ENSRNOT00000087845.3
      Conserved Domains (4) summary
      COG2319
      Location:608 → 1004
      WD40; WD40 repeat [General function prediction only]
      pfam12871
      Location:87 → 166
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      sd00039
      Location:680 → 709
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:677 → 965
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_017594194.3 → XP_017449683.1  cytoplasmic dynein 2 intermediate chain 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K1X3, A0A8I5ZSL7
      Conserved Domains (3) summary
      PTZ00121
      Location:5 → 395
      PTZ00121; MAEBL; Provisional
      COG2319
      Location:574 → 970
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:646 → 675
      7WD40; WD40 repeat [structural motif]

    9. XM_017594197.3 → XP_017449686.1  cytoplasmic dynein 2 intermediate chain 1 isoform X7

      Conserved Domains (3) summary
      PTZ00121
      Location:16 → 356
      PTZ00121; MAEBL; Provisional
      COG2319
      Location:534 → 930
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:606 → 635
      7WD40; WD40 repeat [structural motif]

    10. XM_063262030.1 → XP_063118100.1  cytoplasmic dynein 2 intermediate chain 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZSL7

    RNA

    1. XR_001838171.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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