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    Dtx3 deltex E3 ubiquitin ligase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500847, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dtx3provided by RGD
    Official Full Name
    deltex E3 ubiquitin ligase 3provided by RGD
    Primary source
    RGD:1566181
    See related
    EnsemblRapid:ENSRNOG00000005129 AllianceGenome:RGD:1566181
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566181
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in Notch signaling pathway and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Orthologous to human DTX3 (deltex E3 ubiquitin ligase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 134.5), Kidney (RPKM 60.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtx3 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64898693..64904636, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63013769..63018431, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70476737..70482852, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 1 Neighboring gene solute carrier family 26, member 10 Neighboring gene Rho guanine nucleotide exchange factor 25 Neighboring gene uncharacterized LOC134479708 Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Neighboring gene kinesin family member 5A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Kishi N, et al. Int J Dev Neurosci, 2001 Feb. PMID 11226752
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase DTX3
    Names
    deltex 3 homolog
    deltex 3, E3 ubiquitin ligase
    deltex homolog 3
    protein deltex-3
    NP_001178918.1
    XP_063120177.1
    XP_063120178.1
    XP_063120179.1
    XP_063120180.1
    XP_063120181.1
    XP_063120182.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191989.1 → NP_001178918.1  probable E3 ubiquitin-protein ligase DTX3

      See identical proteins and their annotated locations for NP_001178918.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F1LY78
      Related
      ENSRNOP00000108888.1, ENSRNOT00000159022.1
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      64898693..64904636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264108.1 → XP_063120178.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    2. XM_063264107.1 → XP_063120177.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    3. XM_063264109.1 → XP_063120179.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      Related
      ENSRNOP00000070751.3, ENSRNOT00000090057.3

    4. XM_063264112.1 → XP_063120182.1  probable E3 ubiquitin-protein ligase DTX3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYQ5

    5. XM_063264110.1 → XP_063120180.1  probable E3 ubiquitin-protein ligase DTX3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYQ5

    6. XM_063264111.1 → XP_063120181.1  probable E3 ubiquitin-protein ligase DTX3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYQ5
    Nucleotide Protein Strain
    Heading Accession and Version

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