Phldb1 pleckstrin homology-like domain, family B, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Phldb1provided by RGD
Official Full Name: pleckstrin homology-like domain, family B, member 1provided by RGD
Primary source: RGD:620878
See related: EnsemblRapid:ENSRNOG00000026985 AllianceGenome:RGD:620878
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ll5
Summary: Predicted to be involved in regulation of embryonic development; regulation of epithelial to mesenchymal transition; and regulation of microtubule cytoskeleton organization. Predicted to be located in several cellular components, including cytosol; intercellular bridge; and plasma membrane. Predicted to be active in basal cortex. Human ortholog(s) of this gene implicated in osteogenesis imperfecta. Orthologous to human PHLDB1 (pleckstrin homology like domain family B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 361.3), Brain (RPKM 144.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (53900338..53948325, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (45003543..45051541, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (48997189..49045176, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AU047883 (e-PCR)
- UniSTS:110083

BI278154 (e-PCR)
- UniSTS:244248

BE106591 (e-PCR)
- UniSTS:246322

AU041016 (e-PCR)
- UniSTS:159867

RH140559 (e-PCR)
- UniSTS:222628

AU047896 (e-PCR)
- UniSTS:110070

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastrulation	IEA Inferred from Electronic Annotation more info
involved_in regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basal cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in basal cortex	IEA Inferred from Electronic Annotation more info
located_in basal cortex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pleckstrin homology-like domain family B member 1

Names: protein LL5-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191578.3 → NP_001178507.1 pleckstrin homology-like domain family B member 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6A9F1, D3ZNS1

Related

ENSRNOP00000046235.4, ENSRNOT00000047303.6

Conserved Domains (7) summary

cd14673
Location:1259 → 1374

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00169
Location:1262 → 1369

PH; PH domain

pfam00498
Location:64 → 124

FHA; FHA domain

pfam10846
Location:242 → 540

DUF2722; Protein of unknown function (DUF2722)

pfam14988
Location:730 → 935

DUF4515; Domain of unknown function (DUF4515)

cd16269
Location:777 → 790

GBP_C; coiled coil [structural motif]

cl20817
Location:718 → 805

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001400943.2 → NP_001387872.1 pleckstrin homology-like domain family B member 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6A9F1, A0A8I6AMV1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

53900338..53948325 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264879.1 → XP_063120949.1 pleckstrin homology-like domain family B member 1 isoform X44

UniProtKB/TrEMBL

A0A8I6GJD6

Related

ENSRNOP00000091125.1, ENSRNOT00000100408.2
XM_063264878.1 → XP_063120948.1 pleckstrin homology-like domain family B member 1 isoform X43

UniProtKB/TrEMBL

A0A8I6GJD6

Related

ENSRNOP00000101860.1, ENSRNOT00000149118.1
XM_063264877.1 → XP_063120947.1 pleckstrin homology-like domain family B member 1 isoform X42

UniProtKB/TrEMBL

A0A0G2JV32
XM_039080760.2 → XP_038936688.1 pleckstrin homology-like domain family B member 1 isoform X5

UniProtKB/TrEMBL

A0A8I6A9F1

Conserved Domains (4) summary

PHA03307
Location:143 → 547

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:712 → 944

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1467 → 1582

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00498
Location:64 → 124

FHA; FHA domain
XM_063264880.1 → XP_063120950.1 pleckstrin homology-like domain family B member 1 isoform X44

UniProtKB/TrEMBL

A0A8I6GJD6
XM_063264876.1 → XP_063120946.1 pleckstrin homology-like domain family B member 1 isoform X41

UniProtKB/TrEMBL

A0A0G2JV32
XM_063264875.1 → XP_063120945.1 pleckstrin homology-like domain family B member 1 isoform X40

UniProtKB/TrEMBL

A0A0G2JV32

Related

ENSRNOP00000069330.1, ENSRNOT00000088034.3
XM_063264872.1 → XP_063120942.1 pleckstrin homology-like domain family B member 1 isoform X36

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264868.1 → XP_063120938.1 pleckstrin homology-like domain family B member 1 isoform X32

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264870.1 → XP_063120940.1 pleckstrin homology-like domain family B member 1 isoform X34

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264863.1 → XP_063120933.1 pleckstrin homology-like domain family B member 1 isoform X27

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264860.1 → XP_063120930.1 pleckstrin homology-like domain family B member 1 isoform X24

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264859.1 → XP_063120929.1 pleckstrin homology-like domain family B member 1 isoform X23

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264854.1 → XP_063120924.1 pleckstrin homology-like domain family B member 1 isoform X19

UniProtKB/TrEMBL

A0A8I6A9F1

Related

ENSRNOP00000087775.2, ENSRNOT00000114831.2
XM_063264864.1 → XP_063120934.1 pleckstrin homology-like domain family B member 1 isoform X28

UniProtKB/TrEMBL

A0A8I6A9F1

Related

ENSRNOP00000096080.2, ENSRNOT00000096683.2
XM_063264862.1 → XP_063120932.1 pleckstrin homology-like domain family B member 1 isoform X26

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264861.1 → XP_063120931.1 pleckstrin homology-like domain family B member 1 isoform X25

UniProtKB/TrEMBL

A0A8I6A9F1

Related

ENSRNOP00000109174.1, ENSRNOT00000170158.1
XM_063264858.1 → XP_063120928.1 pleckstrin homology-like domain family B member 1 isoform X22

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264852.1 → XP_063120922.1 pleckstrin homology-like domain family B member 1 isoform X17

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264850.1 → XP_063120920.1 pleckstrin homology-like domain family B member 1 isoform X15

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264849.1 → XP_063120919.1 pleckstrin homology-like domain family B member 1 isoform X14

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264847.1 → XP_063120917.1 pleckstrin homology-like domain family B member 1 isoform X12

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264845.1 → XP_063120915.1 pleckstrin homology-like domain family B member 1 isoform X10

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264844.1 → XP_063120914.1 pleckstrin homology-like domain family B member 1 isoform X9

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264874.1 → XP_063120944.1 pleckstrin homology-like domain family B member 1 isoform X39

UniProtKB/TrEMBL

A0A8I6GJD6
XM_063264873.1 → XP_063120943.1 pleckstrin homology-like domain family B member 1 isoform X38

UniProtKB/TrEMBL

A0A8I6GJD6

Related

ENSRNOP00000068824.3, ENSRNOT00000078816.3
XM_063264869.1 → XP_063120939.1 pleckstrin homology-like domain family B member 1 isoform X33

UniProtKB/TrEMBL

A0A8I6GJD6
XM_039080773.1 → XP_038936701.1 pleckstrin homology-like domain family B member 1 isoform X37

UniProtKB/TrEMBL

A0A0G2JV32

Conserved Domains (4) summary

PHA03307
Location:143 → 547

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:712 → 944

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1270 → 1374

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00498
Location:64 → 124

FHA; FHA domain
XM_063264867.1 → XP_063120937.1 pleckstrin homology-like domain family B member 1 isoform X31

UniProtKB/TrEMBL

A0A0G2JV32
XM_063264866.1 → XP_063120936.1 pleckstrin homology-like domain family B member 1 isoform X30

UniProtKB/TrEMBL

A0A0G2JV32
XM_063264865.1 → XP_063120935.1 pleckstrin homology-like domain family B member 1 isoform X29

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264855.1 → XP_063120925.1 pleckstrin homology-like domain family B member 1 isoform X20

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264851.1 → XP_063120921.1 pleckstrin homology-like domain family B member 1 isoform X16

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264846.1 → XP_063120916.1 pleckstrin homology-like domain family B member 1 isoform X11

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264853.1 → XP_063120923.1 pleckstrin homology-like domain family B member 1 isoform X18

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264848.1 → XP_063120918.1 pleckstrin homology-like domain family B member 1 isoform X13

UniProtKB/TrEMBL

A0A8I6A9F1

Related

ENSRNOP00000094780.2, ENSRNOT00000103833.2
XM_063264842.1 → XP_063120912.1 pleckstrin homology-like domain family B member 1 isoform X7

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264843.1 → XP_063120913.1 pleckstrin homology-like domain family B member 1 isoform X8

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264841.1 → XP_063120911.1 pleckstrin homology-like domain family B member 1 isoform X6

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264840.1 → XP_063120910.1 pleckstrin homology-like domain family B member 1 isoform X3

UniProtKB/TrEMBL

A0A8I6A9F1
XM_039080764.1 → XP_038936692.1 pleckstrin homology-like domain family B member 1 isoform X4

UniProtKB/TrEMBL

A0A8I6A9F1

Conserved Domains (4) summary

PHA03307
Location:143 → 547

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:712 → 944

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1456 → 1560

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00498
Location:64 → 124

FHA; FHA domain
XM_039080762.1 → XP_038936690.1 pleckstrin homology-like domain family B member 1 isoform X2

UniProtKB/TrEMBL

A0A8I6A9F1

Conserved Domains (4) summary

PHA03307
Location:143 → 547

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:712 → 944

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1456 → 1571

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00498
Location:64 → 124

FHA; FHA domain
XM_063264839.1 → XP_063120909.1 pleckstrin homology-like domain family B member 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264856.1 → XP_063120926.1 pleckstrin homology-like domain family B member 1 isoform X21

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264857.1 → XP_063120927.1 pleckstrin homology-like domain family B member 1 isoform X21

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264871.1 → XP_063120941.1 pleckstrin homology-like domain family B member 1 isoform X35

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264881.1 → XP_063120951.1 pleckstrin homology-like domain family B member 1 isoform X45

UniProtKB/TrEMBL

A0A8I6A9F1
XM_063264882.1 → XP_063120952.1 pleckstrin homology-like domain family B member 1 isoform X46

UniProtKB/TrEMBL

A0A8I6GJD6, A6J408

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_134397.1: Suppressed sequence

Description

NM_134397.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.