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    Unc80 unc-80 homolog, NALCN channel complex subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Unc80provided by RGD
    Official Full Name
    unc-80 homolog, NALCN channel complex subunitprovided by RGD
    Primary source
    RGD:1309976
    See related
    EnsemblRapid:ENSRNOG00000028362 AllianceGenome:RGD:1309976
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in plasma membrane. Predicted to be part of sodium channel complex. Orthologous to human UNC80 (unc-80 homolog, NALCN channel complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 204.2) and Adrenal (RPKM 20.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Unc80 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    65
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (75461618..75639849)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (68011940..68190135)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (73492907..73686578)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene splicing regulatory glutamic acid and lysine rich protein 1, pseudogene 1 Neighboring gene microtubule-associated protein 2 Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene ribulose-5-phosphate-3-epimerase Neighboring gene U7 small nuclear RNA Neighboring gene acyl-CoA dehydrogenase, long chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. UNC80 mutation causes a syndrome of hypotonia, severe intellectual disability, dyskinesia and dysmorphism, similar to that caused by mutations in its interacting cation channel NALCN. Perez Y, et al. J Med Genet, 2016 Jun. PMID 26545877
    2. The interdependence of glycolytic and pentose cycle intermediates in ad libitum fed rats. Casazza JP, et al. J Biol Chem, 1986 Jan 15. PMID 3079759
    3. A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis. Veech RL. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12721358, Free PMC Article
    4. The pentose phosphate pathway in the endoplasmic reticulum. Bublitz C, et al. J Biol Chem, 1988 Sep 15. PMID 2843500
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of sodium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein unc-80 homolog
    Names
    unc-80 homolog, NALCN activator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      75461618..75639849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084598.2 → XP_038940526.1  protein unc-80 homolog isoform X1

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    2. XM_063268134.1 → XP_063124204.1  protein unc-80 homolog isoform X8

    3. XM_063268135.1 → XP_063124205.1  protein unc-80 homolog isoform X9

    4. XM_063268136.1 → XP_063124206.1  protein unc-80 homolog isoform X10

      Related
      ENSRNOP00000104902.1, ENSRNOT00000142637.1

    5. XM_063268130.1 → XP_063124200.1  protein unc-80 homolog isoform X2

    6. XM_063268137.1 → XP_063124207.1  protein unc-80 homolog isoform X11

    7. XM_063268133.1 → XP_063124203.1  protein unc-80 homolog isoform X5

    8. XM_039084601.2 → XP_038940529.1  protein unc-80 homolog isoform X12

      Related
      ENSRNOP00000068926.3, ENSRNOT00000089478.3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    9. XM_063268138.1 → XP_063124208.1  protein unc-80 homolog isoform X13

    10. XM_063268131.1 → XP_063124201.1  protein unc-80 homolog isoform X3

    11. XM_039084599.2 → XP_038940527.1  protein unc-80 homolog isoform X6

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    12. XM_039084600.2 → XP_038940528.1  protein unc-80 homolog isoform X7

      UniProtKB/TrEMBL
      D3ZXX3
      Related
      ENSRNOP00000035988.5, ENSRNOT00000032430.6
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    13. XM_063268139.1 → XP_063124209.1  protein unc-80 homolog isoform X14

    14. XM_063268140.1 → XP_063124210.1  protein unc-80 homolog isoform X15

      UniProtKB/TrEMBL
      A0A0G2JU17

    15. XM_063268132.1 → XP_063124202.1  protein unc-80 homolog isoform X4

    16. XM_039084602.2 → XP_038940530.1  protein unc-80 homolog isoform X17

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    17. XM_063268141.1 → XP_063124211.1  protein unc-80 homolog isoform X16

    Nucleotide Protein Strain
    Heading Accession and Version

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