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    Arhgap42 Rho GTPase activating protein 42 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgap42provided by RGD
    Official Full Name
    Rho GTPase activating protein 42provided by RGD
    Primary source
    RGD:1564081
    See related
    EnsemblRapid:ENSRNOG00000026821 AllianceGenome:RGD:1564081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564081
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within negative regulation of Rho protein signal transduction; negative regulation of systemic arterial blood pressure; and negative regulation of vascular associated smooth muscle contraction. Predicted to be located in cytoplasm and synapse. Orthologous to human ARHGAP42 (Rho GTPase activating protein 42). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 88.4), Lung (RPKM 79.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap42 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (14436478..14666588, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (6154759..6384497, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (7210999..7446215, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351649 Neighboring gene progesterone receptor Neighboring gene mitochondrial pyruvate carrier 1-like, pseudogene 2 Neighboring gene transfer RNA alanine (anticodon AGC) 60

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Bai X, et al. Nat Commun, 2013. PMID 24335996, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein 42; rho GTPase-activating protein 42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430509.1 → NP_001417438.1  Rho GTPase activating protein 42 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZY47, A0A8I6APV4

    2. NM_001430510.1 → NP_001417439.1  Rho GTPase activating protein 42 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZLH0, F1M2Q1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      14436478..14666588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_576354.9 → XP_576354.3  rho GTPase-activating protein 42 isoform X1

      Related
      ENSRNOP00000095180.2, ENSRNOT00000102910.2
      Conserved Domains (5) summary
      cd07634
      Location:19 → 225
      BAR_GAP10-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
      cd12066
      Location:821 → 875
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd01249
      Location:267 → 376
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 369
      PH; PH domain
      cl02570
      Location:369 → 567
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. XM_006242515.4 → XP_006242577.1  rho GTPase-activating protein 42 isoform X2

      Related
      ENSRNOP00000101347.1, ENSRNOT00000149409.1
      Conserved Domains (5) summary
      cd12066
      Location:772 → 826
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd01249
      Location:218 → 327
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:218 → 320
      PH; PH domain
      cl02570
      Location:320 → 518
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:1 → 176
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version

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