Rad21l1 RAD21 cohesin complex component like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rad21l1provided by RGD
Official Full Name: RAD21 cohesin complex component like 1provided by RGD
Primary source: RGD:1587557
See related: EnsemblRapid:ENSRNOG00000022335 AllianceGenome:RGD:1587557
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to act upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and seminiferous tubule development. Predicted to be located in lateral element. Predicted to be part of meiotic cohesin complex. Orthologous to human RAD21L1 (RAD21 cohesin complex component like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 10.7), Brain (RPKM 4.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (160620500..160648716, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (140160128..140188324, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (147163335..147191008, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within double-strand break repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope	ISO Inferred from Sequence Orthology more info
involved_in replication-born double-strand break repair via sister chromatid exchange	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within seminiferous tubule development	ISO Inferred from Sequence Orthology more info
involved_in sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptonemal complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in lateral element	ISO Inferred from Sequence Orthology more info
part_of meiotic cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of meiotic cohesin complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RAD21 cohesin complex component like 1; double-strand-break repair protein rad21-like protein 1

Names: RAD21-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430750.1 → NP_001417679.1 RAD21 cohesin complex component like 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

D4ADQ7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

160620500..160648716 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001072159.6 → XP_001072159.4 double-strand-break repair protein rad21-like protein 1

Related

ENSRNOP00000052321.4, ENSRNOT00000055455.5

Conserved Domains (2) summary

pfam04824
Location:500 → 549

Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein

pfam04825
Location:1 → 104

Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein