U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Gskip GSK3B interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362778, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gskipprovided by RGD
    Official Full Name
    GSK3B interacting proteinprovided by RGD
    Primary source
    RGD:1308470
    See related
    AllianceGenome:RGD:1308470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308470
    Summary
    Predicted to enable protein kinase A regulatory subunit binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of protein kinase activity; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human GSKIP (GSK3B interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 63.6), Lung (RPKM 58.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gskip in Genome Data Viewer
    Location:
    6q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (130357241..130373221)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (124586087..124609106)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (129512950..129536320)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene bradykinin receptor B1 Neighboring gene autophagy related 2B Neighboring gene uncharacterized LOC134479256 Neighboring gene adenylate kinase 7 Neighboring gene poly (A) polymerase alpha Neighboring gene transfer RNA proline (anticodon AGG) 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    GSK3B-interacting protein
    Names
    GSK3-beta interaction protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014198.2NP_001014220.2  GSK3B-interacting protein

      See identical proteins and their annotated locations for NP_001014220.2

      Status: VALIDATED

      Source sequence(s)
      AA819750, BC087681, FM111441
      UniProtKB/Swiss-Prot
      Q5PPI3
      UniProtKB/TrEMBL
      A0A0H2UHD3, A6KBD3
      Conserved Domains (1) summary
      pfam05303
      Location:38138
      DUF727; Protein of unknown function (DUF727)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      130357241..130373221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)