Uts2b urotensin 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uts2bprovided by RGD
Official Full Name: urotensin 2Bprovided by RGD
Primary source: RGD:727977
See related: EnsemblRapid:ENSRNOG00000038512 AllianceGenome:RGD:727977
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: U2B; Urp; Uts2d
Summary: Enables G protein-coupled receptor binding activity. Involved in regulation of blood pressure. Predicted to be located in extracellular region. Orthologous to human UTS2B (urotensin 2B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 5.1), Muscle (RPKM 1.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (86929210..86944255)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (73424385..73439429)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (76833761..76848808)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrated that UII and URP binding sites are totally overlapping and that these sites were functional in regions bordering the fourth ventricle; data support a role for UII/URP at the interface between brain parenchyma and cerebrospinal fluid
Title: Concordant localization of functional urotensin II and urotensin II-related peptide binding sites in the rat brain: Atypical occurrence close to the fourth ventricle.
U-II and URP can differentially modulate nuclear UT functions such as gene expression, and both ligands can reach the internal cellular space through a receptor-independent mechanism
Title: Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart.
remarkable cellular and subcellular distribution led us to test the effect of URP on the GnRH-induced gonadotrophins release in the anterior pituitary, and to discuss its putative role at the level of the median eminence
Title: Direct evidence for the co-expression of URP and GnRH in a sub-population of rat hypothalamic neurones: anatomical and functional correlation.
In the aorta, expression levels of urotensin II-related peptide mRNA was significantly elevated in 11-12-week-old SHR compared with age-matched WKY, similarly to those in the kidney.
Title: Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1.
Increased expression of urotensin II-related peptide in kidney with hypertension or renal failure
Title: Increased expression of urotensin II-related peptide and its receptor in kidney with hypertension or renal failure.
SHR are more sensitive than WKY rats to UII, which acts primarily to lower glomerular filtration rate thus favoring salt retention in this model of hypertension
Title: Enhanced renal sensitivity of the spontaneously hypertensive rat to urotensin II.
Data suggest that urotensin II and urotensin II-related peptide reduce cardiac ischemia-reperfusion injury by increasing flow through the coronary circulation, reducing contractility and energy demand, and inhibiting reperfusion myocardial damage.
Title: Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury.
Data suggest that the expression of urotensin II-related peptide, urotensin II and urotensin II receptor is enhanced in failing heart, and the UII/URP/UT-R system has important pathophysiological roles in the progression of heart failure.
Title: Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure.
These results suggest that urotensin II-related peptide is the endogenous and functional ligand for the urotensin II receptor GPR14 in the rat and mouse, and possibly in the human.
Title: Another ligand fishing for G protein-coupled receptor 14. Discovery of urotensin II-related peptide in the rat brain.
The long-lasting vasoconstriction induced by hU-II alone is PKC dependent and associated with PKC-theta phosphorylation.
Title: Role of PKC in the novel synergistic action of urotensin II and angiotensin II and in urotensin II-induced vasoconstriction.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: urotensin-2B

Names: U-IIB; UIIB; urotensin 2 domain containing; urotensin II-related peptide; urotensin IIB; urotensin-2 domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.