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    Fut7 fucosyltransferase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fut7provided by RGD
    Official Full Name
    fucosyltransferase 7provided by RGD
    Primary source
    RGD:735019
    See related
    EnsemblRapid:ENSRNOG00000014156 AllianceGenome:RGD:735019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fuc-TVII; FucT-VII
    Summary
    Enables alpha-(1->3)-fucosyltransferase activity. Involved in inflammatory response. Predicted to be located in trans-Golgi network. Orthologous to human FUT7 (fucosyltransferase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 10.6), Thymus (RPKM 8.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fut7 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28635913..28640407)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8237687..8242273)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2637281..2646497)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene neural proliferation, differentiation and control, 1 Neighboring gene ribosomal protein L28, pseudogene 4 Neighboring gene ATP binding cassette subfamily A member 2 Neighboring gene chloride intracellular channel 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of rat fucosyltransferase VII at sites of inflammation. Niittymäki J, et al. APMIS, 2005 Sep. PMID 16218937
    2. Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene. Bengtson P, et al. J Biol Chem, 2001 Aug 24. PMID 11404359
    3. Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. Natsuka S, et al. J Biol Chem, 1994 Jun 17. PMID 8207002
    4. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. Knibbs RN, et al. J Cell Biol, 1996 May. PMID 8666674, Free PMC Article
    5. Fucosylation of complex glycosphingolipids by recombinant fucosyltransferase-VII. Stroud MR, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299472

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-(1->3)-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryo implantation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leukocyte migration involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte migration involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte migration involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lymphocyte migration into lymph node ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lymphocyte migration into lymph node ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lymphocyte migration into lymphoid organs ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte tethering or rolling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neutrophil migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell adhesion molecule production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of type IV hypersensitivity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-(1,3)-fucosyltransferase 7
    Names
    alpha (1,3) fucosyltransferase
    fucosyltransferase VII
    galactoside 3-L-fucosyltransferase
    selectin ligand synthase
    NP_955785.1
    XP_006233647.1
    XP_006233648.1
    XP_006233649.1
    XP_038960642.1
    XP_038960643.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431519.1 → NP_001418448.1  alpha-(1,3)-fucosyltransferase 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_001431520.1 → NP_001418449.1  alpha-(1,3)-fucosyltransferase 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001431521.1 → NP_001418450.1  alpha-(1,3)-fucosyltransferase 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_199491.3 → NP_955785.1  alpha-(1,3)-fucosyltransferase 7 isoform 2

      See identical proteins and their annotated locations for NP_955785.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q712G6
      Related
      ENSRNOP00000033858.4, ENSRNOT00000037169.6
      Conserved Domains (2) summary
      pfam00852
      Location:197 → 365
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:72 → 182
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28635913..28640407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233587.5 → XP_006233649.1  alpha-(1,3)-fucosyltransferase 7 isoform X5

      Conserved Domains (2) summary
      pfam00852
      Location:145 → 313
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:20 → 130
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. XM_006233585.5 → XP_006233647.1  alpha-(1,3)-fucosyltransferase 7 isoform X1

      Related
      ENSRNOP00000105710.1, ENSRNOT00000169795.1
      Conserved Domains (2) summary
      pfam00852
      Location:207 → 375
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:82 → 192
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    3. XM_006233586.5 → XP_006233648.1  alpha-(1,3)-fucosyltransferase 7 isoform X2

      Conserved Domains (2) summary
      pfam00852
      Location:180 → 348
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:55 → 165
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    4. XM_039104715.2 → XP_038960643.1  alpha-(1,3)-fucosyltransferase 7 isoform X4

      Related
      ENSRNOP00000100129.1, ENSRNOT00000173038.1
      Conserved Domains (2) summary
      pfam00852
      Location:168 → 336
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:43 → 153
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    5. XM_039104714.2 → XP_038960642.1  alpha-(1,3)-fucosyltransferase 7 isoform X3

      UniProtKB/TrEMBL
      A6JT59
      Related
      ENSRNOP00000100712.1, ENSRNOT00000123679.1
      Conserved Domains (2) summary
      pfam00852
      Location:169 → 337
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:44 → 154
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q712G6.1 GenPept UniProtKB/Swiss-Prot:Q712G6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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