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    Polr1h RNA polymerase I subunit H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361784, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr1hprovided by RGD
    Official Full Name
    RNA polymerase I subunit Hprovided by RGD
    Primary source
    RGD:1303114
    See related
    EnsemblRapid:ENSRNOG00000000779 AllianceGenome:RGD:1303114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znrd1; HTEX-6; Tctex6
    Summary
    Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in termination of RNA polymerase I transcription. Predicted to be located in membrane and nucleus. Predicted to be part of RNA polymerase I complex. Orthologous to human POLR1H (RNA polymerase I subunit H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 175.0), Spleen (RPKM 137.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polr1h in Genome Data Viewer
    Location:
    20p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (1600170..1604088)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (1594936..1598854)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2088518..2092436)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RT1 class I, locus M6, gene 1 Neighboring gene RT1 class I, locus M6, gene 2 Neighboring gene ZNRD1 antisense RNA 1 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 11 Neighboring gene ring finger protein 39 Neighboring gene uncharacterized LOC102554813

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene. Hong L, et al. Biochem Biophys Res Commun, 2004 Aug 27. PMID 15358150
    2. Conservation between the RNA polymerase I, II, and III transcription initiation machineries. Vannini A, et al. Mol Cell, 2012 Feb 24. PMID 22365827
    3. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Schneider DA. Gene, 2012 Feb 10. PMID 21893173, Free PMC Article
    4. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in termination of RNA polymerase I transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase I subunit RPA12
    Names
    DNA-directed RNA polymerase I subunit H
    nuclear RNA polymerase I small specific subunit Rpa12 like
    zinc ribbon domain containing 1
    zinc ribbon domain-containing protein 1
    NP_001159772.1
    NP_998732.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166300.1 → NP_001159772.1  DNA-directed RNA polymerase I subunit RPA12

      See identical proteins and their annotated locations for NP_001159772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BX883052, FM113828
      UniProtKB/Swiss-Prot
      Q6MFY5
      UniProtKB/TrEMBL
      A6KR74
      Related
      ENSRNOP00000001012.2, ENSRNOT00000001012.8
      Conserved Domains (2) summary
      COG1594
      Location:16 → 122
      RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
      cd10507
      Location:76 → 122
      Zn-ribbon_RPA12; C-terminal zinc ribbon domain of RPA12 subunit of RNA polymerase I

    2. NM_213567.2 → NP_998732.1  DNA-directed RNA polymerase I subunit RPA12

      See identical proteins and their annotated locations for NP_998732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI232728, BX883052, FM113828
      UniProtKB/Swiss-Prot
      Q6MFY5
      UniProtKB/TrEMBL
      A6KR74
      Related
      ENSRNOP00000098151.2, ENSRNOT00000120491.2
      Conserved Domains (2) summary
      COG1594
      Location:16 → 122
      RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
      cd10507
      Location:76 → 122
      Zn-ribbon_RPA12; C-terminal zinc ribbon domain of RPA12 subunit of RNA polymerase I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      1600170..1604088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MFY5.1 GenPept UniProtKB/Swiss-Prot:Q6MFY5

    Gene LinkOut

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