Spag8 sperm associated antigen 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spag8provided by RGD
Official Full Name: sperm associated antigen 8provided by RGD
Primary source: RGD:1307079
See related: EnsemblRapid:ENSRNOG00000032539 AllianceGenome:RGD:1307079
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in axonemal microtubule and male germ cell nucleus. Predicted to be active in axonemal A tubule inner sheath and nucleus. Orthologous to human SPAG8 (sperm associated antigen 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 182.0), Lung (RPKM 43.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (62697451..62699664, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (57901681..57903894, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (59147412..59149625, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141379 (e-PCR)
- UniSTS:223375

RH141203 (e-PCR)
- UniSTS:223199

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sperm-associated antigen 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173555.1 → NP_001167026.1 sperm-associated antigen 8

Status: PROVISIONAL

Source sequence(s)

BC079031

UniProtKB/TrEMBL

F7EV11, Q6AYI6

Related

ENSRNOP00000050314.4, ENSRNOT00000040641.4

Conserved Domains (1) summary

PHA03247
Location:7 → 203

PHA03247; large tegument protein UL36; Provisional