Tinag tubulointerstitial nephritis antigen [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tinagprovided by RGD
Official Full Name: tubulointerstitial nephritis antigenprovided by RGD
Primary source: RGD:1359482
See related: EnsemblRapid:ENSRNOG00000058120 AllianceGenome:RGD:1359482
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cysteine-type peptidase activity. Predicted to be involved in cell adhesion. Predicted to be located in basement membrane. Orthologous to human TINAG (tubulointerstitial nephritis antigen). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1044.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (86680441..86765485, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (77800031..77885077, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (84122113..84320714, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulointerstitial nephritis antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005549.1 → NP_001005549.1 tubulointerstitial nephritis antigen precursor

See identical proteins and their annotated locations for NP_001005549.1

Status: PROVISIONAL

Source sequence(s)

BC081887

UniProtKB/TrEMBL

A0A0G2K0L8, A0A0G2KAE5, A0A9K3Y6P4, Q66HF6

Related

ENSRNOP00000075369.2, ENSRNOT00000088487.3

Conserved Domains (2) summary

cd02620
Location:217 → 465

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam01033
Location:61 → 104

Somatomedin_B; Somatomedin B domain